---
title: "Gut microbiota: A player in aging and a target for anti-aging…"
description: "Changes in gut bacteria are linked to aging, and modifying these bacteria through diet, probiotics, or fecal transplants may offer anti-aging benefits."
url: "https://magellanlongevity.com/study/microbiome_aging.md"
canonical: "https://magellanlongevity.com/study/microbiome_aging.html"
html: "https://magellanlongevity.com/study/microbiome_aging.html"
type: "study"
study_key: "microbiome_aging"
journal: "Ageing Research Reviews"
year: 2017
pmid: "28109835"
doi: "10.1016/j.arr.2017.01.001"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Gut microbiota: A player in aging and a target for anti-aging intervention

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**HTML version:** https://magellanlongevity.com/study/microbiome_aging.html · **In the Magellan app:** https://magellanlongevity.com/#/study/microbiome_aging

## Citation

| Field | Value |
| --- | --- |
| Journal | Ageing Research Reviews |
| Year | 2017 |
| PMID | [28109835](https://pubmed.ncbi.nlm.nih.gov/28109835/) |
| DOI | [10.1016/j.arr.2017.01.001](https://doi.org/10.1016/j.arr.2017.01.001) |
| Study key | microbiome_aging |

## Takeaway

Changes in gut bacteria are linked to aging, and modifying these bacteria through diet, probiotics, or fecal transplants may offer anti-aging benefits.

## The question

What role does gut microbiota play in aging, and what is the therapeutic potential of microbiome-targeted interventions for anti-aging?

## Hypothesis

The abstract suggests that age-related changes in gut microbiota contribute to aging processes, and that interventions targeting the microbiota could favorably affect host health and aging.

## Methods

This is a review article summarizing recent research findings on the role of gut microbiota in aging processes and the therapeutic potential of microbiome-targeted interventions.

## Results

Aging is associated with alterations in gut microbiota composition, diversity, and function, potentially due to immunosenescence and inflammaging. Microbiota-targeted dietary and probiotic interventions have been shown to enhance antioxidant activity, improve immune homeostasis, suppress chronic inflammation, regulate fat deposition and metabolism, and prevent insulin resistance. Fecal microbiota transplantation has also demonstrated high effectiveness and safety in preventing and treating age-related conditions like atherosclerosis, type 2 diabetes, and Parkinson's disease.

## Conclusion

Gut microbiota plays a significant role in aging processes, and microbiome-targeted interventions, including dietary changes, probiotics, and fecal microbiota transplantation, hold therapeutic potential for anti-aging medicine and the management of age-related pathologies.

## Limitations

As a review, this abstract does not present new experimental data or specific study limitations beyond what might be inherent in the reviewed literature. It summarizes existing findings without detailing the limitations of individual studies.

## Verbatim from the abstract

> Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described, and the gut microbiota is a promising target for anti-aging intervention.

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Glycan-Based Inflammatory Age Testing | — | — |
| Gut Microbiome Testing | — | — |
| AI Nutrition Tracking | — | — |
| At-Home Food & Allergen Testing | Preliminary | [Allergen Alert Mini Food Lab](https://magellanlongevity.com/p/79.md) |

## Reference

1. **Gut microbiota: A player in aging and a target for anti-aging intervention**
   Ageing Research Reviews 2017 · [PMID 28109835](https://pubmed.ncbi.nlm.nih.gov/28109835/) · [DOI 10.1016/j.arr.2017.01.001](https://doi.org/10.1016/j.arr.2017.01.001)

   > Aging-associated alterations in composition, diversity and functional features of intestinal microbiota are well-described, and the gut microbiota is a promising target for anti-aging intervention.

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## Related on Magellan Longevity

- [Allergen Alert Mini Food Lab](https://magellanlongevity.com/p/79.md) — product graded on this and related evidence
- [Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione…](https://magellanlongevity.com/study/glutathione_glynac.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).