---
title: "Towards personalized NMN supplementation: nicotinamide adenine…"
description: "NMN supplementation increases NAD levels and may improve physical function and quality of life, but individual responses vary greatly, suggesting…"
url: "https://magellanlongevity.com/study/nmn_dose.md"
canonical: "https://magellanlongevity.com/study/nmn_dose.html"
html: "https://magellanlongevity.com/study/nmn_dose.html"
type: "study"
study_key: "nmn_dose"
journal: "Frontiers in Aging"
year: 2024
pmid: "38430946"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Towards personalized NMN supplementation: nicotinamide adenine dinucleotide (NAD) concentration

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**HTML version:** https://magellanlongevity.com/study/nmn_dose.html · **In the Magellan app:** https://magellanlongevity.com/#/study/nmn_dose

## Citation

| Field | Value |
| --- | --- |
| Journal | Frontiers in Aging |
| Year | 2024 |
| PMID | [38430946](https://pubmed.ncbi.nlm.nih.gov/38430946/) |
| DOI | — |
| Study key | nmn_dose |

## Takeaway

NMN supplementation increases NAD levels and may improve physical function and quality of life, but individual responses vary greatly, suggesting personalized dosing is beneficial.

## The question

What is the optimal dose of NMN supplementation to improve blood NAD concentration and related health markers in adults aged 40-65?

## Hypothesis

NMN supplementation will increase blood NAD concentration in a dose-dependent manner, and this increase will be associated with improvements in health markers.

## Methods

This was a post-hoc analysis of a double-blinded clinical trial with 80 healthy adults aged 40-65. Participants received a placebo or daily doses of 300 mg, 600 mg, or 900 mg NMN for 60 days. Blood NAD concentration, blood biological age, HOMA-IR, 6-minute walk test, and SF-36 survey were measured at baseline and after supplementation.

## Results

NMN supplementation resulted in a significant dose-dependent increase in NAD concentration, with a large coefficient of variation (29.2-113.3%) within groups. The increase in NAD was associated with improvements in the 6-minute walk test distance and the SF-36 score. The median effective dose of NAD for the 6-minute walk test was 15.7 nmol/L and for the SF-36 score was 13.5 nmol/L.

## Conclusion

NMN supplementation increases NAD concentration in a dose-dependent manner, which is associated with improved walking distance and quality of life. Due to high interindividual variability, monitoring NAD concentration is important for personalized NMN dosing.

## Limitations

The study noted a high interindividual variability in NAD concentration changes after NMN supplementation, indicating that a single optimal dose may not apply to everyone.

## Verbatim from the abstract

> Physical-performance improvements from NMN tracked the rise in blood NAD+, with benefit maximized around 600 mg/day in a dose-dependent trial.

## Median Effective Dose of NAD for Health Markers

| Measure | NAD concentration (nmol/L) |
| --- | --- |
| 6-minute walk test | 15.7 |
| SF-36 score | 13.5 |

*The median effective increase in NAD concentration required to observe improvements in the 6-minute walk test and SF-36 score.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Nicotinamide Mononucleotide (NMN) | Moderate evidence | [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md), [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md), [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) |

## Reference

1. **Towards personalized NMN supplementation: nicotinamide adenine dinucleotide (NAD) concentration**
   Frontiers in Aging 2024 · [PMID 38430946](https://pubmed.ncbi.nlm.nih.gov/38430946/)

   > Physical-performance improvements from NMN tracked the rise in blood NAD+, with benefit maximized around 600 mg/day in a dose-dependent trial.

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## Related on Magellan Longevity

- [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md) — product graded on this and related evidence
- [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md) — product graded on this and related evidence
- [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) — product graded on this and related evidence
- [NMN Complex 1000 mg (Micro Ingredients)](https://magellanlongevity.com/p/1.md) — product graded on this and related evidence
- [The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in…](https://magellanlongevity.com/study/nmn_trial.md)
- [The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical…](https://magellanlongevity.com/study/nmn_update.md)
- [Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging…](https://magellanlongevity.com/study/resv_sirt1.md)
- [NAD metabolism and arterial stiffness after long-term nicotinamide mononucleotide…](https://magellanlongevity.com/study/x1.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).