--- title: "The Safety and Antiaging Effects of Nicotinamide Mononucleotide…" description: "While NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending." url: "https://magellanlongevity.com/study/nmn_update.md" canonical: "https://magellanlongevity.com/study/nmn_update.html" html: "https://magellanlongevity.com/study/nmn_update.html" type: "study" study_key: "nmn_update" journal: "Advances in Nutrition" year: 2023 pmid: "37619764" doi: "10.1016/j.advnut.2023.08.008" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update. [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › The Safety and Antiaging Effects of Nicotinamide… **HTML version:** https://magellanlongevity.com/study/nmn_update.html · **In the Magellan app:** https://magellanlongevity.com/#/study/nmn_update ## Citation | Field | Value | | --- | --- | | Journal | Advances in Nutrition | | Year | 2023 | | PMID | [37619764](https://pubmed.ncbi.nlm.nih.gov/37619764/) | | DOI | [10.1016/j.advnut.2023.08.008](https://doi.org/10.1016/j.advnut.2023.08.008) | | Study key | nmn_update | ## Takeaway While NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending. ## The question What are the safety and antiaging effects of nicotinamide mononucleotide (NMN) in human clinical trials? ## Hypothesis NMN supplementation, by increasing NAD concentration, could mitigate aging-related disorders such as oxidative stress, DNA damage, neurodegeneration, and inflammatory responses in humans, similar to findings in cell and animal models. ## Methods This is a review article summarizing the current progress of human clinical trials investigating NMN supplementation and its effects, along with an overview of NMN/NAD biology. ## Results The review notes that a dozen human clinical trials with NMN supplementation are currently underway. It highlights that in vitro/in vivo studies have demonstrated NMN supplementation increases NAD concentration and could mitigate aging-related disorders. ## Conclusion The review aims to clarify the potential effects of NMN supplementation and suggest future study directions, acknowledging that most existing evidence comes from cell or animal models, with human trial results still emerging. ## Limitations Most studies evaluating the effects of NMN have been conducted in cell or animal models, leading to a concern regarding the safety and physiological effects of NMN supplementation in the human population. ## Verbatim from the abstract > As the NAD concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD status could possibly influence the aging process. ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Nicotinamide Mononucleotide (NMN) | Moderate evidence | [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md), [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md), [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) | | Intracellular NAD⁺ & Longevity Marker Testing | — | — | ## Reference 1. **The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.** Advances in Nutrition 2023 · [PMID 37619764](https://pubmed.ncbi.nlm.nih.gov/37619764/) · [DOI 10.1016/j.advnut.2023.08.008](https://doi.org/10.1016/j.advnut.2023.08.008) > As the NAD concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD status could possibly influence the aging process. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/nmn_update.html#page","url":"https://magellanlongevity.com/study/nmn_update.html","name":"The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.","description":"While NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/nmn_update.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"The Safety and Antiaging Effects of Nicotinamide…","item":"https://magellanlongevity.com/study/nmn_update.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/nmn_update.html#study","name":"The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.","headline":"The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Advances in Nutrition"},"identifier":"PMID:37619764","url":"https://pubmed.ncbi.nlm.nih.gov/37619764/","sameAs":"https://doi.org/10.1016/j.advnut.2023.08.008","abstract":"While NMN shows promise in animal and cell studies for antiaging, human clinical trial data is still largely pending."}]} ``` ## Related on Magellan Longevity - [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md) — product graded on this and related evidence - [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md) — product graded on this and related evidence - [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) — product graded on this and related evidence - [NMN Complex 1000 mg (Micro Ingredients)](https://magellanlongevity.com/p/1.md) — product graded on this and related evidence - [The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in…](https://magellanlongevity.com/study/nmn_trial.md) - [Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging…](https://magellanlongevity.com/study/resv_sirt1.md) - [NAD metabolism and arterial stiffness after long-term nicotinamide mononucleotide…](https://magellanlongevity.com/study/x1.md) - [Towards personalized NMN supplementation: nicotinamide adenine dinucleotide (NAD)…](https://magellanlongevity.com/study/nmn_dose.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).