--- title: "Potential Modulation of Inflammation by Probiotic and Omega-3…" description: "A combined probiotic and omega-3 supplement increased anti-inflammatory markers in elderly individuals, but did not significantly reduce hs-CRP." url: "https://magellanlongevity.com/study/prob_rct.md" canonical: "https://magellanlongevity.com/study/prob_rct.html" html: "https://magellanlongevity.com/study/prob_rct.html" type: "study" study_key: "prob_rct" journal: "Nutrients" year: 2022 pmid: "36235651" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Potential Modulation of Inflammation by Probiotic and… **HTML version:** https://magellanlongevity.com/study/prob_rct.html · **In the Magellan app:** https://magellanlongevity.com/#/study/prob_rct ## Citation | Field | Value | | --- | --- | | Journal | Nutrients | | Year | 2022 | | PMID | [36235651](https://pubmed.ncbi.nlm.nih.gov/36235651/) | | DOI | — | | Study key | prob_rct | ## Takeaway A combined probiotic and omega-3 supplement increased anti-inflammatory markers in elderly individuals, but did not significantly reduce hs-CRP. ## The question Can a combined probiotic and omega-3 supplement reduce low-grade inflammation in elderly individuals? ## Hypothesis The novel combination of a multi-strain probiotic and omega-3 supplements will reduce low-grade inflammation, as measured by high-sensitivity C-reactive protein (hs-CRP), in elderly participants. ## Methods This was a proof-of-concept, randomized, placebo-controlled, parallel study involving 76 community-dwelling elderly participants (median age 71.0 years). Participants received either the dual supplement (n=37) or a placebo (n=39) for eight weeks. Hs-CRP, cytokine levels, and intestinal permeability were assessed at baseline and after the intervention. ## Results No significant difference was observed for hs-CRP between the dual supplement group and placebo. However, supplementation led to significant increases in the anti-inflammatory marker IL-10 and increased levels of valeric acid. ## Conclusion Probiotic and omega-3 dual supplementation exerts modest effects on inflammation, as evidenced by increased IL-10 and valeric acid, and may have potential as a non-pharmacological treatment for low-grade inflammation in the elderly. ## Limitations The study did not find a significant reduction in the primary outcome measure, hs-CRP, suggesting the effects on inflammation might be modest or require different markers. ## Verbatim from the abstract > In older adults, multi-strain probiotic supplementation raised the anti-inflammatory cytokine IL-10 and short-chain fatty acids, although hs-CRP did not differ from placebo. ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Probiotics | Moderate evidence | [Probiotic Multi-Strain (50B CFU)](https://magellanlongevity.com/p/199.md) | ## Reference 1. **Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial** Nutrients 2022 · [PMID 36235651](https://pubmed.ncbi.nlm.nih.gov/36235651/) > In older adults, multi-strain probiotic supplementation raised the anti-inflammatory cytokine IL-10 and short-chain fatty acids, although hs-CRP did not differ from placebo. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/prob_rct.html#page","url":"https://magellanlongevity.com/study/prob_rct.html","name":"Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic…","description":"A combined probiotic and omega-3 supplement increased anti-inflammatory markers in elderly individuals, but did not significantly reduce hs-CRP.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/prob_rct.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Potential Modulation of Inflammation by Probiotic and…","item":"https://magellanlongevity.com/study/prob_rct.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/prob_rct.html#study","name":"Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial","headline":"Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic…","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Nutrients"},"identifier":"PMID:36235651","url":"https://pubmed.ncbi.nlm.nih.gov/36235651/","abstract":"A combined probiotic and omega-3 supplement increased anti-inflammatory markers in elderly individuals, but did not significantly reduce hs-CRP."}]} ``` ## Related on Magellan Longevity - [Probiotic Multi-Strain (50B CFU)](https://magellanlongevity.com/p/199.md) — product graded on this and related evidence - [Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a…](https://magellanlongevity.com/study/akk_human.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).