--- title: "Caloric restriction, resveratrol and melatonin: Role of SIRT1…" description: "Caloric restriction, resveratrol, and melatonin may combat aging and age-related diseases by activating sirtuins and scavenging free radicals." url: "https://magellanlongevity.com/study/resv_sirt1.md" canonical: "https://magellanlongevity.com/study/resv_sirt1.html" html: "https://magellanlongevity.com/study/resv_sirt1.html" type: "study" study_key: "resv_sirt1" journal: "Mechanisms of Ageing and Development" year: 2015 pmid: "25824609" doi: "10.1016/j.mad.2015.03.008" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Caloric restriction, resveratrol and melatonin: Role of… **HTML version:** https://magellanlongevity.com/study/resv_sirt1.html · **In the Magellan app:** https://magellanlongevity.com/#/study/resv_sirt1 ## Citation | Field | Value | | --- | --- | | Journal | Mechanisms of Ageing and Development | | Year | 2015 | | PMID | [25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) | | DOI | [10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008) | | Study key | resv_sirt1 | ## Takeaway Caloric restriction, resveratrol, and melatonin may combat aging and age-related diseases by activating sirtuins and scavenging free radicals. ## The question What roles do caloric restriction, resveratrol, and melatonin play in aging and age-related diseases, particularly concerning sirtuin 1 (SIRT1) activation? ## Hypothesis Free radicals contribute to aging through oxidative damage, but also modulate signaling pathways like those related to sirtuins. Caloric restriction extends lifespan by inducing sirtuins. Resveratrol and melatonin, both sirtuin activators and free radical scavengers, may offer synergistic benefits for health and longevity. ## Methods This abstract is a review and does not describe specific experimental methods. It synthesizes existing research on caloric restriction, resveratrol, and melatonin. ## Results Caloric restriction extends lifespan and improves healthspan, partly by inducing sirtuins. Resveratrol, a polyphenol, has antioxidant, antifungal, and sirtuin-activating properties. Melatonin, an endogenous free radical scavenger that declines with age, also activates sirtuins and has anti-inflammatory and circadian rhythm regulatory functions. Both melatonin and resveratrol are present in foods and may have synergistic effects. ## Conclusion Caloric restriction, resveratrol, and melatonin are implicated in modulating aging processes, partly through their effects on sirtuins, particularly SIRT1. Their presence in diet and potential synergistic actions suggest they could promote health and longevity. ## Limitations This abstract does not present new experimental data or discuss specific limitations of the reviewed studies. It is a conceptual overview. ## Verbatim from the abstract > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1. ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Nicotinamide Mononucleotide (NMN) | Moderate evidence | [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md), [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md), [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) | | NAD⁺ Activation Stack (NMN + Resveratrol + Pterostilbene) | — | — | | Trans-Resveratrol | Moderate evidence | [Purovitalis Liposomal Trans-Resveratrol](https://magellanlongevity.com/p/6.md) | | All-in-One Longevity Formulation | Emerging evidence | [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) | | Polyphenol Antioxidant Blend | Moderate evidence | [DaVinci Labs Phyto Benefits](https://magellanlongevity.com/p/19.md) | ## Reference 1. **Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases** Mechanisms of Ageing and Development 2015 · [PMID 25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) · [DOI 10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008) > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/resv_sirt1.html#page","url":"https://magellanlongevity.com/study/resv_sirt1.html","name":"Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases","description":"Caloric restriction, resveratrol, and melatonin may combat aging and age-related diseases by activating sirtuins and scavenging free radicals.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/resv_sirt1.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Caloric restriction, resveratrol and melatonin: Role of…","item":"https://magellanlongevity.com/study/resv_sirt1.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/resv_sirt1.html#study","name":"Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases","headline":"Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases","datePublished":"2015","isPartOf":{"@type":"Periodical","name":"Mechanisms of Ageing and Development"},"identifier":"PMID:25824609","url":"https://pubmed.ncbi.nlm.nih.gov/25824609/","sameAs":"https://doi.org/10.1016/j.mad.2015.03.008","abstract":"Caloric restriction, resveratrol, and melatonin may combat aging and age-related diseases by activating sirtuins and scavenging free radicals."}]} ``` ## Related on Magellan Longevity - [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md) — product graded on this and related evidence - [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md) — product graded on this and related evidence - [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) — product graded on this and related evidence - [DaVinci Labs Phyto Benefits](https://magellanlongevity.com/p/19.md) — product graded on this and related evidence - [The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in…](https://magellanlongevity.com/study/nmn_trial.md) - [The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical…](https://magellanlongevity.com/study/nmn_update.md) - [NAD metabolism and arterial stiffness after long-term nicotinamide mononucleotide…](https://magellanlongevity.com/study/x1.md) - [Towards personalized NMN supplementation: nicotinamide adenine dinucleotide (NAD)…](https://magellanlongevity.com/study/nmn_dose.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).