--- title: "Fisetin is a senotherapeutic that extends health and lifespan." description: "Fisetin, a natural flavonoid, acts as a potent senolytic in mice and human tissues, reducing age-related pathology and extending lifespan when…" url: "https://magellanlongevity.com/study/s101.md" canonical: "https://magellanlongevity.com/study/s101.html" html: "https://magellanlongevity.com/study/s101.html" type: "study" study_key: "s101" journal: "EBioMedicine" year: 2018 pmid: "30279143" doi: "10.1016/j.ebiom.2018.09.015" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Fisetin is a senotherapeutic that extends health and lifespan. [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Fisetin is a senotherapeutic that extends health and… **HTML version:** https://magellanlongevity.com/study/s101.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s101 ## Citation | Field | Value | | --- | --- | | Journal | EBioMedicine | | Year | 2018 | | PMID | [30279143](https://pubmed.ncbi.nlm.nih.gov/30279143/) | | DOI | [10.1016/j.ebiom.2018.09.015](https://doi.org/10.1016/j.ebiom.2018.09.015) | | Study key | s101 | ## Takeaway Fisetin, a natural flavonoid, acts as a potent senolytic in mice and human tissues, reducing age-related pathology and extending lifespan when administered late in life. ## The question Can flavonoids be identified that have more potent senolytic activity than previously known combinations, and can these extend health and lifespan? ## Hypothesis The researchers hypothesized that certain flavonoid polyphenols would exhibit potent senolytic activity, potentially surpassing existing treatments, and that this activity could translate into improved health and extended lifespan in animal models. ## Methods A panel of 10 flavonoid polyphenols was screened for senolytic activity using senescent murine and human fibroblasts. The most potent flavonoid, fisetin, was then tested in mice modeling a progeroid syndrome and in aged wild-type mice to assess its effects on senescence markers, age-related histopathology, disease markers, health span, and lifespan. Human adipose tissue explants were also used to evaluate the translatability of the results. ## Results Fisetin was identified as the most potent senolytic among the 10 flavonoids tested. Acute or intermittent treatment with fisetin reduced senescence markers in multiple tissues in progeroid and old mice, indicating a 'hit-and-run' senolytic mechanism. Fisetin also reduced senescence in specific cell types within murine and human adipose tissue. In wild-type mice, late-life administration of fisetin restored tissue homeostasis, reduced age-related pathology, and extended both median and maximum lifespan. ## Conclusion The natural product fisetin possesses senotherapeutic activity in mice and human tissues. Intervention with fisetin late in life was sufficient to provide significant health benefits, suggesting its potential for translation into human clinical studies. ## Limitations The study primarily used mouse models and human tissue explants, which may not fully reflect the complexity of human aging and disease. The specific mechanisms of fisetin's cell-type specificity were not fully elucidated. ## Verbatim from the abstract > fisetin was the most potent senolytic ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | All-in-One Longevity Formulation | Emerging evidence | [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) | | Fisetin Senolytic Capsules | Emerging evidence | [Fisetin Senolytic Capsules](https://magellanlongevity.com/p/101.md) | ## Reference 1. **Fisetin is a senotherapeutic that extends health and lifespan.** EBioMedicine 2018 · [PMID 30279143](https://pubmed.ncbi.nlm.nih.gov/30279143/) · [DOI 10.1016/j.ebiom.2018.09.015](https://doi.org/10.1016/j.ebiom.2018.09.015) > fisetin was the most potent senolytic ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s101.html#page","url":"https://magellanlongevity.com/study/s101.html","name":"Fisetin is a senotherapeutic that extends health and lifespan.","description":"Fisetin, a natural flavonoid, acts as a potent senolytic in mice and human tissues, reducing age-related pathology and extending lifespan when…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s101.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Fisetin is a senotherapeutic that extends health and…","item":"https://magellanlongevity.com/study/s101.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s101.html#study","name":"Fisetin is a senotherapeutic that extends health and lifespan.","headline":"Fisetin is a senotherapeutic that extends health and lifespan.","datePublished":"2018","isPartOf":{"@type":"Periodical","name":"EBioMedicine"},"identifier":"PMID:30279143","url":"https://pubmed.ncbi.nlm.nih.gov/30279143/","sameAs":"https://doi.org/10.1016/j.ebiom.2018.09.015","abstract":"Fisetin, a natural flavonoid, acts as a potent senolytic in mice and human tissues, reducing age-related pathology and extending lifespan when administered late in life."}]} ``` ## Related on Magellan Longevity - [Fisetin Senolytic Capsules](https://magellanlongevity.com/p/101.md) — product graded on this and related evidence - [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) — product graded on this and related evidence - [The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in…](https://magellanlongevity.com/study/nmn_trial.md) - [Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging…](https://magellanlongevity.com/study/resv_sirt1.md) - [Induction of autophagy by spermidine promotes longevity.](https://magellanlongevity.com/study/spermidine_autophagy.md) - [Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the…](https://magellanlongevity.com/study/akg_krebs.md) - [Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione…](https://magellanlongevity.com/study/glutathione_glynac.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).