---
title: "Urolithin A improves muscle strength, exercise performance, and…"
description: "Urolithin A supplementation improved muscle strength and exercise performance in middle-aged adults, along with markers of mitochondrial health."
url: "https://magellanlongevity.com/study/s102.md"
canonical: "https://magellanlongevity.com/study/s102.html"
html: "https://magellanlongevity.com/study/s102.html"
type: "study"
study_key: "s102"
journal: "Cell Rep Med"
year: 2022
pmid: "35584623"
doi: "10.1016/j.xcrm.2022.100633"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.

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**HTML version:** https://magellanlongevity.com/study/s102.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s102

## Citation

| Field | Value |
| --- | --- |
| Journal | Cell Rep Med |
| Year | 2022 |
| PMID | [35584623](https://pubmed.ncbi.nlm.nih.gov/35584623/) |
| DOI | [10.1016/j.xcrm.2022.100633](https://doi.org/10.1016/j.xcrm.2022.100633) |
| Study key | s102 |

## Takeaway

Urolithin A supplementation improved muscle strength and exercise performance in middle-aged adults, along with markers of mitochondrial health.

## The question

Can Urolithin A improve muscle strength, exercise performance, and biomarkers of mitochondrial health in middle-aged adults?

## Hypothesis

Targeting mitophagy to activate the recycling of faulty mitochondria during aging with Urolithin A will mitigate muscle decline.

## Methods

This was a randomized, placebo-controlled trial where middle-aged adults received either Urolithin A (Mitopure) at two different doses or a placebo for 4 months. The study assessed muscle strength, aerobic endurance (peak oxygen consumption), physical performance (6-minute walk test), peak power output, plasma acylcarnitines, C-reactive proteins, and expression of proteins linked to mitophagy and mitochondrial metabolism in skeletal muscle.

## Results

Urolithin A intake led to significant improvements in muscle strength (approximately 12%). Clinically meaningful improvements were observed in aerobic endurance (peak oxygen consumption) and physical performance (6-minute walk test). However, there was no significant improvement in peak power output. Plasma acylcarnitines and C-reactive proteins were significantly lower with Urolithin A, and there was a significant increase in the expression of proteins linked to mitophagy and mitochondrial metabolism in skeletal muscle.

## Conclusion

Urolithin A improves muscle performance, muscle strength, aerobic endurance, and physical performance, and positively impacts biomarkers of mitochondrial health and inflammation in middle-aged adults.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> significant improvements in muscle strength with intake of Urolithin A

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Urolithin A (Mitopure) | Moderate evidence | [Urolithin A (Mitopure)](https://magellanlongevity.com/p/102.md) |
| Pomegranate Ellagitannin Extract | Moderate evidence | [Pomegranate Ellagitannin Extract](https://magellanlongevity.com/p/110.md) |

## Reference

1. **Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults.**
   Cell Rep Med 2022 · [PMID 35584623](https://pubmed.ncbi.nlm.nih.gov/35584623/) · [DOI 10.1016/j.xcrm.2022.100633](https://doi.org/10.1016/j.xcrm.2022.100633)

   > significant improvements in muscle strength with intake of Urolithin A

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## Related on Magellan Longevity

- [Urolithin A (Mitopure)](https://magellanlongevity.com/p/102.md) — product graded on this and related evidence
- [Pomegranate Ellagitannin Extract](https://magellanlongevity.com/p/110.md) — product graded on this and related evidence
- [Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in…](https://magellanlongevity.com/study/d35050355.md)
- [Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery,…](https://magellanlongevity.com/study/d40839339.md)
- [Evidence: precursor to urolithins, mitophagy](https://magellanlongevity.com/study/s110.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).