--- title: "Evidence: oleuropein lowers BP and LDL" description: "Olive leaf extract may help lower blood pressure and cholesterol in pre-hypertensive men." url: "https://magellanlongevity.com/study/s109.md" canonical: "https://magellanlongevity.com/study/s109.html" html: "https://magellanlongevity.com/study/s109.html" type: "study" study_key: "s109" journal: "Eur J Nutr" year: 2016 pmid: "26951205" doi: "10.1007/s00394-016-1188-y" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: oleuropein lowers BP and LDL [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: oleuropein lowers BP and LDL **HTML version:** https://magellanlongevity.com/study/s109.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s109 ## Citation | Field | Value | | --- | --- | | Journal | Eur J Nutr | | Year | 2016 | | PMID | [26951205](https://pubmed.ncbi.nlm.nih.gov/26951205/) | | DOI | [10.1007/s00394-016-1188-y](https://doi.org/10.1007/s00394-016-1188-y) | | Study key | s109 | ## Takeaway Olive leaf extract may help lower blood pressure and cholesterol in pre-hypertensive men. ## The question What are the effects of a phenolic-rich olive leaf extract (OLE) on blood pressure and associated vascular and metabolic measures in pre-hypertensive males? ## Hypothesis The study hypothesized that a phenolic-rich olive leaf extract would favorably modify cardiovascular risk markers such as blood pressure, endothelial function, and plasma lipids. ## Methods This was a randomized, double-blind, controlled, crossover trial involving 60 pre-hypertensive males. Participants consumed either OLE (136 mg oleuropein; 6 mg hydroxytyrosol) or a polyphenol-free control daily for 6 weeks, followed by a 4-week washout period before switching to the alternate arm. ## Results Compared to the control, OLE intake significantly lowered daytime SBP by 3.95 mmHg, 24-h SBP by 3.33 mmHg, daytime DBP by 3.00 mmHg, and 24-h DBP by 2.42 mmHg. OLE also reduced plasma total cholesterol by 0.32 mmol/L, LDL cholesterol by 0.19 mmol/L, triglycerides by 0.18 mmol/L, and interleukin-8 by 0.63 pg/ml. Other markers of inflammation, vascular function, and glucose metabolism were not affected. ## Conclusion The study concluded that olive leaf extract intake has hypotensive and lipid-lowering effects in pre-hypertensive males, supporting previous research. ## Limitations The abstract does not explicitly state any limitations of the study. ## Verbatim from the abstract > hypotensive and lipid-lowering effects in vivo ## Changes in Blood Pressure and Lipids with Olive Leaf Extract | Measure | Reduction (mmHg or mmol/L or pg/ml) | | --- | --- | | Daytime SBP Reduction | 3.95 | | 24-h SBP Reduction | 3.33 | | Daytime DBP Reduction | 3 | | 24-h DBP Reduction | 2.42 | | Total Cholesterol Reduction | 0.32 | | LDL Cholesterol Reduction | 0.19 | | Triglycerides Reduction | 0.18 | | Interleukin-8 Reduction | 0.63 | *Reductions in blood pressure, lipids, and interleukin-8 observed after olive leaf extract intake compared to control.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Olive Leaf Extract (Oleuropein) | Moderate evidence | [Olive Leaf Extract (Oleuropein)](https://magellanlongevity.com/p/109.md) | ## Reference 1. **Evidence: oleuropein lowers BP and LDL** Eur J Nutr 2016 · [PMID 26951205](https://pubmed.ncbi.nlm.nih.gov/26951205/) · [DOI 10.1007/s00394-016-1188-y](https://doi.org/10.1007/s00394-016-1188-y) > hypotensive and lipid-lowering effects in vivo ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s109.html#page","url":"https://magellanlongevity.com/study/s109.html","name":"Evidence: oleuropein lowers BP and LDL","description":"Olive leaf extract may help lower blood pressure and cholesterol in pre-hypertensive men.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s109.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: oleuropein lowers BP and LDL","item":"https://magellanlongevity.com/study/s109.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s109.html#study","name":"Evidence: oleuropein lowers BP and LDL","headline":"Evidence: oleuropein lowers BP and LDL","datePublished":"2016","isPartOf":{"@type":"Periodical","name":"Eur J Nutr"},"identifier":"PMID:26951205","url":"https://pubmed.ncbi.nlm.nih.gov/26951205/","sameAs":"https://doi.org/10.1007/s00394-016-1188-y","abstract":"Olive leaf extract may help lower blood pressure and cholesterol in pre-hypertensive men."}]} ``` ## Related on Magellan Longevity - [Olive Leaf Extract (Oleuropein)](https://magellanlongevity.com/p/109.md) — product graded on this and related evidence - [Olive leaf extract effect on cardiometabolic profile among adults with prehypertension…](https://magellanlongevity.com/study/d33868820.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).