--- title: "Evidence: improves endothelial function, lowers BP" description: "A specific grape seed extract improved markers of endothelial function in cells and lowered blood pressure in healthy human volunteers, also showing a…" url: "https://magellanlongevity.com/study/s111.md" canonical: "https://magellanlongevity.com/study/s111.html" html: "https://magellanlongevity.com/study/s111.html" type: "study" study_key: "s111" journal: "Nutrients" year: 2021 pmid: "33671310" doi: "10.3390/nu13020654" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: improves endothelial function, lowers BP [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: improves endothelial function, lowers BP **HTML version:** https://magellanlongevity.com/study/s111.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s111 ## Citation | Field | Value | | --- | --- | | Journal | Nutrients | | Year | 2021 | | PMID | [33671310](https://pubmed.ncbi.nlm.nih.gov/33671310/) | | DOI | [10.3390/nu13020654](https://doi.org/10.3390/nu13020654) | | Study key | s111 | ## Takeaway A specific grape seed extract improved markers of endothelial function in cells and lowered blood pressure in healthy human volunteers, also showing a positive effect on perceived stress. ## The question What are the effects of a specific grape seed extract (GSEe) on vascular inflammation, vasodilation, and blood pressure in both in vitro and human models? ## Hypothesis The study hypothesized that GSEe, a standardized grape seed extract, would positively modulate endothelial function and blood pressure. ## Methods The study used an in vitro human umbilical vein endothelial cell (HUVEC) model to assess GSEe's effects on vascular inflammation and vasodilation markers. A randomized, double-blind, placebo-controlled clinical study was also conducted in healthy volunteers, with participants receiving 300 mg/day of GSEe tablets for 16 weeks, to investigate its benefits on blood pressure and mood. ## Results In HUVEC cells, GSEe significantly reduced the secretion/release of soluble Inter-Cellular Adhesion Molecule-1 (sICAM) and endothelin-1. In healthy human volunteers, GSEe supplementation significantly modulated blood pressure, showing a more pronounced effect compared to placebo. This blood pressure modulation was observed in the male subgroup, where no placebo effect was noted, unlike in the female group. Additionally, GSEe showed a positive modulation on mood related to stress perception. ## Conclusion GSEe beneficially modulates endothelial functionality and blood pressure. It also relieved perceived stress, suggesting potential for mood comfort. ## Limitations The abstract does not explicitly state any limitations of the study. ## Verbatim from the abstract > both supplementations significantly modulated blood pressure ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Grape Seed Extract | Moderate evidence | [Grape Seed Extract](https://magellanlongevity.com/p/111.md) | ## Reference 1. **Evidence: improves endothelial function, lowers BP** Nutrients 2021 · [PMID 33671310](https://pubmed.ncbi.nlm.nih.gov/33671310/) · [DOI 10.3390/nu13020654](https://doi.org/10.3390/nu13020654) > both supplementations significantly modulated blood pressure ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s111.html#page","url":"https://magellanlongevity.com/study/s111.html","name":"Evidence: improves endothelial function, lowers BP","description":"A specific grape seed extract improved markers of endothelial function in cells and lowered blood pressure in healthy human volunteers, also showing a…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s111.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: improves endothelial function, lowers BP","item":"https://magellanlongevity.com/study/s111.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s111.html#study","name":"Evidence: improves endothelial function, lowers BP","headline":"Evidence: improves endothelial function, lowers BP","datePublished":"2021","isPartOf":{"@type":"Periodical","name":"Nutrients"},"identifier":"PMID:33671310","url":"https://pubmed.ncbi.nlm.nih.gov/33671310/","sameAs":"https://doi.org/10.3390/nu13020654","abstract":"A specific grape seed extract improved markers of endothelial function in cells and lowered blood pressure in healthy human volunteers, also showing a positive effect on perceived stress."}]} ``` ## Related on Magellan Longevity - [Grape Seed Extract](https://magellanlongevity.com/p/111.md) — product graded on this and related evidence - [Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in…](https://magellanlongevity.com/study/d31757033.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).