---
title: "Evidence: lowers adhesion molecules, BP"
description: "Hesperidin 2S may offer cardiovascular benefits by reducing adhesion molecules and blood pressure, particularly in overweight individuals with a…"
url: "https://magellanlongevity.com/study/s113.md"
canonical: "https://magellanlongevity.com/study/s113.html"
html: "https://magellanlongevity.com/study/s113.html"
type: "study"
study_key: "s113"
journal: "Am J Clin Nutr"
year: 2016
pmid: "27797708"
doi: "10.3945/ajcn.116.136960"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: lowers adhesion molecules, BP

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## Citation

| Field | Value |
| --- | --- |
| Journal | Am J Clin Nutr |
| Year | 2016 |
| PMID | [27797708](https://pubmed.ncbi.nlm.nih.gov/27797708/) |
| DOI | [10.3945/ajcn.116.136960](https://doi.org/10.3945/ajcn.116.136960) |
| Study key | s113 |

## Takeaway

Hesperidin 2S may offer cardiovascular benefits by reducing adhesion molecules and blood pressure, particularly in overweight individuals with a relatively healthy endothelium.

## The question

Does hesperidin 2S supplementation improve endothelial function in overweight individuals?

## Hypothesis

Hesperidin, a citrus flavonoid, may exert beneficial effects on endothelial function due to its antioxidant and other biological properties.

## Methods

This was a randomized, double-blind, placebo-controlled study where 68 overweight individuals received either 450 mg/d of hesperidin 2S or a placebo for 6 weeks. Researchers assessed flow-mediated dilation (FMD), soluble adhesion molecules (sVCAM-1, sICAM-1, sP-selectin), systolic blood pressure (SBP), and diastolic blood pressure (DBP) at baseline and after 6 weeks. Acute endothelial dysfunction was induced by a high-fat meal, with FMD and adhesion molecules measured postprandially. An exploratory analysis was also conducted in subjects with baseline FMD "3%.

## Results

No significant change in fasting or postprandial FMD was observed in the total study population after 6 weeks of hesperidin intake. However, there was a trend for a reduction in sVCAM-1, sICAM-1, sP-selectin, SBP, and DBP after 6 weeks of hesperidin treatment. In the exploratory analysis of subjects with baseline FMD ≥3%, hesperidin protected individuals from postprandial endothelial dysfunction (P = 0.050) and significantly downregulated sVCAM-1 and sICAM-1 (all P ≥0.030).

## Conclusion

Six weeks of hesperidin 2S consumption did not improve basal or postprandial FMD in the overall study population, but showed a tendency to reduce adhesion molecules and blood pressure. In overweight and obese individuals with a relatively healthy endothelium (baseline FMD ≥3%), hesperidin 2S improved endothelial dysfunction after a high-fat meal and reduced adhesion molecules, suggesting cardiovascular health benefits.

## Limitations

The results reported were not adjusted for multiplicity. The significant findings regarding FMD and adhesion molecules were from an exploratory analysis in a subgroup of participants.

## Verbatim from the abstract

> hesperidin protected individuals from postprandial endothelial dysfunction

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Hesperidin Citrus Flavonoid | Moderate evidence | [Hesperidin Citrus Flavonoid](https://magellanlongevity.com/p/113.md) |

## Reference

1. **Evidence: lowers adhesion molecules, BP**
   Am J Clin Nutr 2016 · [PMID 27797708](https://pubmed.ncbi.nlm.nih.gov/27797708/) · [DOI 10.3945/ajcn.116.136960](https://doi.org/10.3945/ajcn.116.136960)

   > hesperidin protected individuals from postprandial endothelial dysfunction

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## Related on Magellan Longevity

- [Hesperidin Citrus Flavonoid](https://magellanlongevity.com/p/113.md) — product graded on this and related evidence
- [Citrus polyphenol hesperidin stimulates nitric oxide production while improving…](https://magellanlongevity.com/study/d21346065.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).