---
title: "Evidence: inhibits neuroinflammation, ER stress"
description: "Luteolin improved memory and reduced brain inflammation and cellular stress in a mouse model of Alzheimer's disease."
url: "https://magellanlongevity.com/study/s115.md"
canonical: "https://magellanlongevity.com/study/s115.html"
html: "https://magellanlongevity.com/study/s115.html"
type: "study"
study_key: "s115"
journal: "Acta Pharmacol Sin"
year: 2021
pmid: "34267346"
doi: "10.1038/s41401-021-00702-8"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: inhibits neuroinflammation, ER stress

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**HTML version:** https://magellanlongevity.com/study/s115.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s115

## Citation

| Field | Value |
| --- | --- |
| Journal | Acta Pharmacol Sin |
| Year | 2021 |
| PMID | [34267346](https://pubmed.ncbi.nlm.nih.gov/34267346/) |
| DOI | [10.1038/s41401-021-00702-8](https://doi.org/10.1038/s41401-021-00702-8) |
| Study key | s115 |

## Takeaway

Luteolin improved memory and reduced brain inflammation and cellular stress in a mouse model of Alzheimer's disease.

## The question

Can luteolin improve memory deficits and reduce neuroinflammation in a triple-transgenic mouse model of Alzheimer's disease?

## Hypothesis

Luteolin, a flavonoid with known anti-inflammatory and neuroprotective properties, will have beneficial effects on memory deficits and neuroinflammation in 3xTg-AD mice.

## Methods

Triple-transgenic Alzheimer's disease (3xTg-AD) mice were treated with luteolin at doses of 20 or 40 mg/kg/day via intraperitoneal injection for 3 weeks. The study also used rat C6 glioma cells treated with luteolin (1 or 10 µM) to investigate its effects on LPS-induced cell proliferation, inflammatory cytokine release, and ER stress.

## Results

Luteolin treatment dose-dependently improved spatial learning and memory deficits in 3xTg-AD mice. This was accompanied by inhibition of astrocyte overactivation (GFAP), reduced neuroinflammation (TNF-α, IL-1β, IL-6, NO, COX-2, iNOS protein), and decreased expression of ER stress markers (GRP78, IRE1α) in brain tissues. In rat C6 glioma cells, luteolin dose-dependently inhibited LPS-induced cell proliferation, excessive inflammatory cytokine release, and an increase in the ER stress marker GRP78.

## Conclusion

Luteolin is an effective agent for treating learning and memory deficits in 3xTg-AD mice, likely due to its inhibition of ER stress in astrocytes and subsequent reduction of neuroinflammation.

## Limitations

The study was conducted in a mouse model and rat glioma cells, which may not fully translate to human Alzheimer's disease. The specific mechanisms linking ER stress inhibition in astrocytes to improved memory were not fully elucidated.

## Verbatim from the abstract

> Luteolin alleviates cognitive impairment via inhibiting neuroinflammation

## Luteolin Doses Administered to 3xTg-AD Mice

| Measure | Dose (mg/kg/day) |
| --- | --- |
| Luteolin Dose 1 | 20 |
| Luteolin Dose 2 | 40 |

*Luteolin was administered at two different doses to triple-transgenic Alzheimer's disease mice.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Luteolin Capsules | Emerging evidence | [Luteolin Capsules](https://magellanlongevity.com/p/115.md) |

## Reference

1. **Evidence: inhibits neuroinflammation, ER stress**
   Acta Pharmacol Sin 2021 · [PMID 34267346](https://pubmed.ncbi.nlm.nih.gov/34267346/) · [DOI 10.1038/s41401-021-00702-8](https://doi.org/10.1038/s41401-021-00702-8)

   > Luteolin alleviates cognitive impairment via inhibiting neuroinflammation

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## Related on Magellan Longevity

- [Luteolin Capsules](https://magellanlongevity.com/p/115.md) — product graded on this and related evidence
- [Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice](https://magellanlongevity.com/study/d26918466.md)
- [Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma](https://magellanlongevity.com/study/d33098588.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).