--- title: "Evidence: promotes mitochondrial biogenesis" description: "PQQ shows promise in preventing and treating pulmonary hypertension by improving mitochondrial function and reducing cellular proliferation and…" url: "https://magellanlongevity.com/study/s122.md" canonical: "https://magellanlongevity.com/study/s122.html" html: "https://magellanlongevity.com/study/s122.html" type: "study" study_key: "s122" journal: "Pulm Pharmacol Ther" year: 2022 pmid: "36030026" doi: "10.1016/j.pupt.2022.102156" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: promotes mitochondrial biogenesis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: promotes mitochondrial biogenesis **HTML version:** https://magellanlongevity.com/study/s122.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s122 ## Citation | Field | Value | | --- | --- | | Journal | Pulm Pharmacol Ther | | Year | 2022 | | PMID | [36030026](https://pubmed.ncbi.nlm.nih.gov/36030026/) | | DOI | [10.1016/j.pupt.2022.102156](https://doi.org/10.1016/j.pupt.2022.102156) | | Study key | s122 | ## Takeaway PQQ shows promise in preventing and treating pulmonary hypertension by improving mitochondrial function and reducing cellular proliferation and inflammation. ## The question What are the effects of pyrroloquinoline quinone (PQQ) on cellular proliferation, apoptosis resistance, mitochondrial and metabolic alterations associated with pulmonary hypertension (PH)? ## Hypothesis The study hypothesizes that PQQ, known to promote mitochondrial biogenesis, may have beneficial effects on the cellular and mitochondrial dysregulations contributing to pulmonary hypertension. ## Methods Human pulmonary artery smooth muscle cells (HPASMCs), endothelial cells (PAECs), and primary cultured cardiomyocytes were exposed to hypoxia to induce a PH-like phenotype. Sprague Dawley rats were injected with monocrotaline (MCT) (60 mg/kg, SC, once) to induce pulmonary hypertension. PQQ treatment (2 mg/kg, PO, for 35 days) was administered to the MCT-treated rats. ## Results PQQ treatment attenuated cellular proliferation and promoted apoptosis via a mitochondrial-dependent pathway. In HPASMCs, PQQ prevented mitochondrial and metabolic dysfunctions, improved mitochondrial bioenergetics, preserved respiratory complexes, and reduced insulin resistance. In MCT-treated rats, PQQ treatment (both preventive and curative) significantly attenuated the increase in right ventricle pressure and hypertrophy, reduced endothelial dysfunction and pulmonary artery remodeling, prevented cardiac fibrosis, improved cardiac functions, and reduced inflammation. ## Conclusion PQQ can attenuate mitochondrial and metabolic abnormalities in PASMCs and prevent the development of PH in MCT-treated rats, suggesting its potential as a therapeutic agent for PH. ## Limitations The abstract does not explicitly state any limitations of the study. ## Verbatim from the abstract > PQQ is known to promote mitochondrial biogenesis and improved mitochondrial bioenergetics ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | PQQ (Pyrroloquinoline Quinone) | Moderate evidence | [PQQ (Pyrroloquinoline Quinone)](https://magellanlongevity.com/p/122.md) | ## Reference 1. **Evidence: promotes mitochondrial biogenesis** Pulm Pharmacol Ther 2022 · [PMID 36030026](https://pubmed.ncbi.nlm.nih.gov/36030026/) · [DOI 10.1016/j.pupt.2022.102156](https://doi.org/10.1016/j.pupt.2022.102156) > PQQ is known to promote mitochondrial biogenesis and improved mitochondrial bioenergetics ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s122.html#page","url":"https://magellanlongevity.com/study/s122.html","name":"Evidence: promotes mitochondrial biogenesis","description":"PQQ shows promise in preventing and treating pulmonary hypertension by improving mitochondrial function and reducing cellular proliferation and…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s122.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: promotes mitochondrial biogenesis","item":"https://magellanlongevity.com/study/s122.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s122.html#study","name":"Evidence: promotes mitochondrial biogenesis","headline":"Evidence: promotes mitochondrial biogenesis","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Pulm Pharmacol Ther"},"identifier":"PMID:36030026","url":"https://pubmed.ncbi.nlm.nih.gov/36030026/","sameAs":"https://doi.org/10.1016/j.pupt.2022.102156","abstract":"PQQ shows promise in preventing and treating pulmonary hypertension by improving mitochondrial function and reducing cellular proliferation and inflammation."}]} ``` ## Related on Magellan Longevity - [PQQ (Pyrroloquinoline Quinone)](https://magellanlongevity.com/p/122.md) — product graded on this and related evidence - [Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in…](https://magellanlongevity.com/study/d34415830.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).