---
title: "Evidence: ATP/phosphocreatine energy buffer"
description: "Creatine supplementation combined with resistance training may help improve muscle and bone health in older adults and could be a treatment for frailty…"
url: "https://magellanlongevity.com/study/s123.md"
canonical: "https://magellanlongevity.com/study/s123.html"
html: "https://magellanlongevity.com/study/s123.html"
type: "study"
study_key: "s123"
journal: "Bone"
year: 2022
pmid: "35688360"
doi: "10.1016/j.bone.2022.116467"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: ATP/phosphocreatine energy buffer

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: ATP/phosphocreatine energy buffer

**HTML version:** https://magellanlongevity.com/study/s123.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s123

## Citation

| Field | Value |
| --- | --- |
| Journal | Bone |
| Year | 2022 |
| PMID | [35688360](https://pubmed.ncbi.nlm.nih.gov/35688360/) |
| DOI | [10.1016/j.bone.2022.116467](https://doi.org/10.1016/j.bone.2022.116467) |
| Study key | s123 |

## Takeaway

Creatine supplementation combined with resistance training may help improve muscle and bone health in older adults and could be a treatment for frailty and cachexia.

## The question

What are the effects of creatine supplementation on indices of aging muscle and bone, and can it be justified for treating frailty and cachexia in older adults?

## Hypothesis

Creatine monohydrate supplementation, especially with resistance training, may have favorable effects on aging muscle and bone, potentially making it a viable intervention for frailty and cachexia.

## Methods

This is a narrative review that updates existing research on creatine supplementation's effects on aging muscle and bone, including bone turnover markers. It also presents a rationale for its use in treating frailty and cachexia in older adults.

## Results

The review indicates that creatine monohydrate supplementation, particularly when combined with resistance training, shows favorable effects on markers of aging muscle and bone. These musculoskeletal benefits suggest a potential role for creatine in addressing frailty and cachexia.

## Conclusion

Creatine supplementation, especially with resistance training, appears to have beneficial effects on aging muscle and bone, providing a possible justification for its use in treating frailty and cachexia in older adults.

## Limitations

This is a narrative review, which synthesizes existing literature but does not present new experimental data. The specific details of the 'evidence' are not quantified within this abstract.

## Verbatim from the abstract

> creatine monohydrate has favorable effects on indices of aging muscle and bone

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Creatine Monohydrate | Strong evidence | [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) |

## Reference

1. **Evidence: ATP/phosphocreatine energy buffer**
   Bone 2022 · [PMID 35688360](https://pubmed.ncbi.nlm.nih.gov/35688360/) · [DOI 10.1016/j.bone.2022.116467](https://doi.org/10.1016/j.bone.2022.116467)

   > creatine monohydrate has favorable effects on indices of aging muscle and bone

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## Related on Magellan Longevity

- [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — product graded on this and related evidence
- [Resistance training and creatine supplementation on oxidative stress, muscle strength…](https://magellanlongevity.com/study/d37206869.md)
- [The Additive Effects of Creatine Supplementation and Exercise Training in an Aging…](https://magellanlongevity.com/study/d30762623.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).