---
title: "Evidence: conditionally essential amino acid"
description: "Taurine levels decline with age, and supplementing taurine improved health and longevity in animals, suggesting it may play a role in human aging."
url: "https://magellanlongevity.com/study/s124.md"
canonical: "https://magellanlongevity.com/study/s124.html"
html: "https://magellanlongevity.com/study/s124.html"
type: "study"
study_key: "s124"
journal: "Science"
year: 2023
pmid: "37289866"
doi: "10.1126/science.abn9257"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: conditionally essential amino acid

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: conditionally essential amino acid

**HTML version:** https://magellanlongevity.com/study/s124.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s124

## Citation

| Field | Value |
| --- | --- |
| Journal | Science |
| Year | 2023 |
| PMID | [37289866](https://pubmed.ncbi.nlm.nih.gov/37289866/) |
| DOI | [10.1126/science.abn9257](https://doi.org/10.1126/science.abn9257) |
| Study key | s124 |

## Takeaway

Taurine levels decline with age, and supplementing taurine improved health and longevity in animals, suggesting it may play a role in human aging.

## The question

Does taurine deficiency contribute to aging, and can taurine supplementation improve health span and life span?

## Hypothesis

Taurine deficiency is a driver of aging, and its reversal through supplementation can increase health span and life span.

## Methods

The study observed circulating taurine levels in aging mice, monkeys, and humans. It then investigated the effects of taurine supplementation on health span and life span in mice and monkeys. Mechanistic studies examined taurine's impact on cellular senescence, telomerase deficiency, mitochondrial dysfunction, DNA damage, and inflammaging. Human data correlated taurine concentrations with age-related diseases and measured taurine levels after acute endurance exercise.

## Results

Circulating taurine concentrations declined with aging in mice, monkeys, and humans. Taurine supplementation increased health span and life span in mice, and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases, and taurine concentrations increased after acute endurance exercise.

## Conclusion

Taurine deficiency may be a driver of aging, as its reversal through supplementation increased health span in worms, rodents, and primates, and life span in worms and rodents. Clinical trials are warranted to investigate this in humans.

## Limitations

The study notes that human data showed correlations and an increase after exercise, but direct intervention trials in humans to assess taurine's impact on aging were not conducted. The findings in worms, rodents, and primates need to be confirmed in human clinical trials.

## Verbatim from the abstract

> taurine supplementation increased the health span and life span in mice and health span in monkeys

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Taurine | Moderate evidence | [Taurine](https://magellanlongevity.com/p/124.md) |

## Reference

1. **Evidence: conditionally essential amino acid**
   Science 2023 · [PMID 37289866](https://pubmed.ncbi.nlm.nih.gov/37289866/) · [DOI 10.1126/science.abn9257](https://doi.org/10.1126/science.abn9257)

   > taurine supplementation increased the health span and life span in mice and health span in monkeys

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## Related on Magellan Longevity

- [Taurine](https://magellanlongevity.com/p/124.md) — product graded on this and related evidence
- [Taurine as a biomarker for aging: A new avenue for translational research](https://magellanlongevity.com/study/d38435677.md)
- [Effects of taurine supplementation following eccentric exercise in young adults](https://magellanlongevity.com/study/taurine_muscle.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).