---
title: "Evidence: brain-penetrant magnesium"
description: "A supplement containing magnesium L-threonate, phosphatidylserine, and vitamins C and D improved memory and cognition in healthy Chinese adults, with…"
url: "https://magellanlongevity.com/study/s127.md"
canonical: "https://magellanlongevity.com/study/s127.html"
html: "https://magellanlongevity.com/study/s127.html"
type: "study"
study_key: "s127"
journal: "Nutrients"
year: 2022
pmid: "36558392"
doi: "10.3390/nu14245235"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: brain-penetrant magnesium

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: brain-penetrant magnesium

**HTML version:** https://magellanlongevity.com/study/s127.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s127

## Citation

| Field | Value |
| --- | --- |
| Journal | Nutrients |
| Year | 2022 |
| PMID | [36558392](https://pubmed.ncbi.nlm.nih.gov/36558392/) |
| DOI | [10.3390/nu14245235](https://doi.org/10.3390/nu14245235) |
| Study key | s127 |

## Takeaway

A supplement containing magnesium L-threonate, phosphatidylserine, and vitamins C and D improved memory and cognition in healthy Chinese adults, with older individuals showing more benefit.

## The question

Does MagteinPS, a formulation containing magnesium L-threonate, phosphatidylserine, and vitamins C and D, improve cognitive function in healthy Chinese adults?

## Hypothesis

MagteinPS will effectively raise magnesium levels in the brain and neurons, leading to improved memory and cognition.

## Methods

This was a double-blind, placebo-controlled study involving 109 healthy Chinese adults aged 18-65 years. Participants were randomly assigned to receive either 2 g/day of MagteinPS or a placebo (starch) for 30 days. Cognitive function was assessed using "The Clinical Memory Test" before and after the supplementation period.

## Results

Subjects receiving MagteinPS showed significant improvements over the control group in all five subcategories of "The Clinical Memory Test" and in overall memory quotient scores. Older participants demonstrated greater improvement compared to younger participants.

## Conclusion

MagteinPS significantly improved memory and cognition in healthy Chinese adults.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> significant improvements in overall memory quotient scores

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Magnesium L-Threonate | Emerging evidence | [Magnesium L-Threonate](https://magellanlongevity.com/p/127.md) |

## Reference

1. **Evidence: brain-penetrant magnesium**
   Nutrients 2022 · [PMID 36558392](https://pubmed.ncbi.nlm.nih.gov/36558392/) · [DOI 10.3390/nu14245235](https://doi.org/10.3390/nu14245235)

   > significant improvements in overall memory quotient scores

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## Related on Magellan Longevity

- [Magnesium L-Threonate](https://magellanlongevity.com/p/127.md) — product graded on this and related evidence
- [Regulation of structural and functional synapse density by L-threonate through…](https://magellanlongevity.com/study/d27178134.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).