--- title: "Evidence: methyl donor, homocysteine remethylation" description: "Daily low-dose B vitamins and betaine supplementation can reduce high homocysteine levels in Chinese adults." url: "https://magellanlongevity.com/study/s132.md" canonical: "https://magellanlongevity.com/study/s132.html" html: "https://magellanlongevity.com/study/s132.html" type: "study" study_key: "s132" journal: "Eur J Nutr" year: 2023 pmid: "36717385" doi: "10.1007/s00394-023-03087-y" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: methyl donor, homocysteine remethylation [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: methyl donor, homocysteine remethylation **HTML version:** https://magellanlongevity.com/study/s132.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s132 ## Citation | Field | Value | | --- | --- | | Journal | Eur J Nutr | | Year | 2023 | | PMID | [36717385](https://pubmed.ncbi.nlm.nih.gov/36717385/) | | DOI | [10.1007/s00394-023-03087-y](https://doi.org/10.1007/s00394-023-03087-y) | | Study key | s132 | ## Takeaway Daily low-dose B vitamins and betaine supplementation can reduce high homocysteine levels in Chinese adults. ## The question Can daily low-dose B vitamins plus betaine supplementation reduce plasma homocysteine concentrations in Chinese adults with hyperhomocysteinemia who are not exposed to mandatory folic acid fortification? ## Hypothesis Daily supplementation with low-dose B vitamins plus betaine will significantly reduce plasma homocysteine concentrations in Chinese adults with hyperhomocysteinemia. ## Methods One hundred healthy Chinese adults with hyperhomocysteinemia were randomly assigned to either a supplement group (400 μg folic acid, 8 mg vitamin B, 6.4 μg vitamin B, and 1 g betaine daily) or a placebo group for 12 weeks. Fasting blood was collected at baseline, week 4, and week 12 to measure homocysteine, folate, vitamin B, and betaine concentrations. Generalized estimation equations were used for statistical analysis. ## Results The supplement group showed significant increases in blood folate, vitamin B, and betaine concentrations, indicating good compliance. At baseline, homocysteine levels were similar between groups. After 12 weeks, the supplement group had a significant reduction in plasma homocysteine concentrations compared to the placebo group (mean group difference -3.87; reduction rate 10.1%). This decrease was associated with increased blood folate and betaine concentrations. ## Conclusion Daily supplementation with low-dose B vitamins plus betaine for 12 weeks effectively decreased plasma homocysteine concentrations in Chinese adults with hyperhomocysteinemia. ## Limitations The abstract does not explicitly state any limitations of the study. ## Verbatim from the abstract > low-dose B vitamins plus betaine effectively decreased plasma homocysteine ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Betaine (TMG) | Strong evidence | [Betaine (TMG)](https://magellanlongevity.com/p/132.md) | ## Reference 1. **Evidence: methyl donor, homocysteine remethylation** Eur J Nutr 2023 · [PMID 36717385](https://pubmed.ncbi.nlm.nih.gov/36717385/) · [DOI 10.1007/s00394-023-03087-y](https://doi.org/10.1007/s00394-023-03087-y) > low-dose B vitamins plus betaine effectively decreased plasma homocysteine ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s132.html#page","url":"https://magellanlongevity.com/study/s132.html","name":"Evidence: methyl donor, homocysteine remethylation","description":"Daily low-dose B vitamins and betaine supplementation can reduce high homocysteine levels in Chinese adults.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s132.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: methyl donor, homocysteine remethylation","item":"https://magellanlongevity.com/study/s132.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s132.html#study","name":"Evidence: methyl donor, homocysteine remethylation","headline":"Evidence: methyl donor, homocysteine remethylation","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Eur J Nutr"},"identifier":"PMID:36717385","url":"https://pubmed.ncbi.nlm.nih.gov/36717385/","sameAs":"https://doi.org/10.1007/s00394-023-03087-y","abstract":"Daily low-dose B vitamins and betaine supplementation can reduce high homocysteine levels in Chinese adults."}]} ``` ## Related on Magellan Longevity - [Betaine (TMG)](https://magellanlongevity.com/p/132.md) — product graded on this and related evidence - [Betaine supplementation modulates betaine concentration by MTHFR genotype in healthy…](https://magellanlongevity.com/study/d38876040.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).