--- title: "Evidence: enzymatic cofactor (300+ reactions)" description: "Oral magnesium supplementation can modestly lower both systolic and diastolic blood pressure in adults." url: "https://magellanlongevity.com/study/s136.md" canonical: "https://magellanlongevity.com/study/s136.html" html: "https://magellanlongevity.com/study/s136.html" type: "study" study_key: "s136" journal: "Hypertension" year: 2016 pmid: "27402922" doi: "10.1161/HYPERTENSIONAHA.116.07664" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: enzymatic cofactor (300+ reactions) [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: enzymatic cofactor (300+ reactions) **HTML version:** https://magellanlongevity.com/study/s136.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s136 ## Citation | Field | Value | | --- | --- | | Journal | Hypertension | | Year | 2016 | | PMID | [27402922](https://pubmed.ncbi.nlm.nih.gov/27402922/) | | DOI | [10.1161/HYPERTENSIONAHA.116.07664](https://doi.org/10.1161/HYPERTENSIONAHA.116.07664) | | Study key | s136 | ## Takeaway Oral magnesium supplementation can modestly lower both systolic and diastolic blood pressure in adults. ## The question Does oral magnesium supplementation reduce blood pressure in adults? ## Hypothesis The researchers hypothesized that oral magnesium supplementation would reduce blood pressure. ## Methods This meta-analysis synthesized evidence from 34 randomized, double-blind, placebo-controlled trials published up to February 1, 2016, involving 2028 normotensive and hypertensive adults. Weighted mean differences of changes in blood pressure and serum magnesium were calculated using a random-effects meta-analysis. ## Results Magnesium supplementation at a median dose of 368 mg/d for a median duration of 3 months significantly reduced systolic blood pressure by 2.00 mm Hg and diastolic blood pressure by 1.78 mm Hg. These reductions were accompanied by a 0.05 mmol/L elevation of serum magnesium. A dose of 300 mg/d or duration of 1 month was found sufficient to elevate serum magnesium and reduce blood pressure, and serum magnesium was negatively associated with diastolic blood pressure. ## Conclusion Magnesium supplementation has a causal effect on lowering blood pressure in adults. ## Limitations Residual heterogeneity may still exist even after considering factors like trial quality and dropout rates. Further well-designed trials are needed to validate the blood pressure-lowering efficacy of optimal magnesium treatment. ## Verbatim from the abstract > magnesium significantly reduced systolic and diastolic blood pressure ## Blood Pressure Reduction with Magnesium Supplementation | Measure | BP Reduction (mm Hg) | | --- | --- | | Systolic BP Reduction | 2 | | Diastolic BP Reduction | 1.78 | *Magnesium supplementation reduced systolic blood pressure by 2.00 mm Hg and diastolic blood pressure by 1.78 mm Hg.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Magnesium Glycinate | Moderate evidence | [Magnesium Glycinate](https://magellanlongevity.com/p/136.md) | | Mineral Remineralization Drops | Emerging evidence | [Mineral Remineralization Drops](https://magellanlongevity.com/p/191.md) | ## Reference 1. **Evidence: enzymatic cofactor (300+ reactions)** Hypertension 2016 · [PMID 27402922](https://pubmed.ncbi.nlm.nih.gov/27402922/) · [DOI 10.1161/HYPERTENSIONAHA.116.07664](https://doi.org/10.1161/HYPERTENSIONAHA.116.07664) > magnesium significantly reduced systolic and diastolic blood pressure ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s136.html#page","url":"https://magellanlongevity.com/study/s136.html","name":"Evidence: enzymatic cofactor (300+ reactions)","description":"Oral magnesium supplementation can modestly lower both systolic and diastolic blood pressure in adults.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s136.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: enzymatic cofactor (300+ reactions)","item":"https://magellanlongevity.com/study/s136.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s136.html#study","name":"Evidence: enzymatic cofactor (300+ reactions)","headline":"Evidence: enzymatic cofactor (300+ reactions)","datePublished":"2016","isPartOf":{"@type":"Periodical","name":"Hypertension"},"identifier":"PMID:27402922","url":"https://pubmed.ncbi.nlm.nih.gov/27402922/","sameAs":"https://doi.org/10.1161/HYPERTENSIONAHA.116.07664","abstract":"Oral magnesium supplementation can modestly lower both systolic and diastolic blood pressure in adults."}]} ``` ## Related on Magellan Longevity - [Mineral Remineralization Drops](https://magellanlongevity.com/p/191.md) — product graded on this and related evidence - [Magnesium Glycinate](https://magellanlongevity.com/p/136.md) — product graded on this and related evidence - [Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of…](https://magellanlongevity.com/study/d41000008.md) - [The Effects of Magnesium Supplementation on Blood Pressure Among Type 2 Diabetes…](https://magellanlongevity.com/study/d32385715.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).