---
title: "Evidence: anti-glycation dipeptide antioxidant"
description: "This study protocol outlines a trial to investigate if carnosine supplementation improves cardiometabolic health and cognitive function in individuals…"
url: "https://magellanlongevity.com/study/s139.md"
canonical: "https://magellanlongevity.com/study/s139.html"
html: "https://magellanlongevity.com/study/s139.html"
type: "study"
study_key: "s139"
journal: "BMJ Open"
year: 2017
pmid: "28864708"
doi: "10.1136/bmjopen-2017-017691"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: anti-glycation dipeptide antioxidant

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: anti-glycation dipeptide antioxidant

**HTML version:** https://magellanlongevity.com/study/s139.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s139

## Citation

| Field | Value |
| --- | --- |
| Journal | BMJ Open |
| Year | 2017 |
| PMID | [28864708](https://pubmed.ncbi.nlm.nih.gov/28864708/) |
| DOI | [10.1136/bmjopen-2017-017691](https://doi.org/10.1136/bmjopen-2017-017691) |
| Study key | s139 |

## Takeaway

This study protocol outlines a trial to investigate if carnosine supplementation improves cardiometabolic health and cognitive function in individuals with pre-diabetes and type 2 diabetes.

## The question

Does carnosine supplementation improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes?

## Hypothesis

The study aims to investigate if carnosine supplementation improves cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes.

## Methods

This will be a parallel design randomized controlled trial. Fifty participants aged 18-70 with pre-diabetes or T2DM (HbA1c < 8%) will be randomly assigned to either an intervention group receiving 2g of carnosine daily or a control group receiving an identical placebo for 14 weeks. Baseline and post-intervention measurements will include anthropometrics, oral glucose tolerance, cardiovascular parameters, cognitive function, physical activity, heart rate variability, liver fibroscan, and questionnaires on dietary habits, sleep, depression, and quality of life. Changes in these parameters will be compared between groups.

## Results

This is a study protocol, and no results are available yet.

## Conclusion

This is a study protocol, and no conclusions can be drawn yet.

## Limitations

This is a study protocol, and limitations of the study design are not discussed in the abstract.

## Verbatim from the abstract

> carnosine preserves insulin sensitivity and secretion in overweight and obese individuals

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Carnosine | Moderate evidence | [Carnosine](https://magellanlongevity.com/p/139.md) |

## Reference

1. **Evidence: anti-glycation dipeptide antioxidant**
   BMJ Open 2017 · [PMID 28864708](https://pubmed.ncbi.nlm.nih.gov/28864708/) · [DOI 10.1136/bmjopen-2017-017691](https://doi.org/10.1136/bmjopen-2017-017691)

   > carnosine preserves insulin sensitivity and secretion in overweight and obese individuals

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## Related on Magellan Longevity

- [Carnosine](https://magellanlongevity.com/p/139.md) — product graded on this and related evidence
- [Effect of carnosine on lipid profile, fasting blood glucose, HbA1C and insulin…](https://magellanlongevity.com/study/d31987255.md)
- [beta-alanine supplementation to improve exercise capacity and performance: a systematic…](https://magellanlongevity.com/study/d27797728.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).