--- title: "Evidence: High-sensitivity C-reactive protein" description: "Higher CTI levels are linked to increased risk of cardiovascular disease and mortality, particularly in individuals without diabetes." url: "https://magellanlongevity.com/study/s142.md" canonical: "https://magellanlongevity.com/study/s142.html" html: "https://magellanlongevity.com/study/s142.html" type: "study" study_key: "s142" journal: "Cardiovasc Diabetol" year: 2025 pmid: "40750895" doi: "10.1186/s12933-025-02835-0" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: High-sensitivity C-reactive protein [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: High-sensitivity C-reactive protein **HTML version:** https://magellanlongevity.com/study/s142.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s142 ## Citation | Field | Value | | --- | --- | | Journal | Cardiovasc Diabetol | | Year | 2025 | | PMID | [40750895](https://pubmed.ncbi.nlm.nih.gov/40750895/) | | DOI | [10.1186/s12933-025-02835-0](https://doi.org/10.1186/s12933-025-02835-0) | | Study key | s142 | ## Takeaway Higher CTI levels are linked to increased risk of cardiovascular disease and mortality, particularly in individuals without diabetes. ## The question What is the association between the C-reactive protein-triglyceride-glucose index (CTI) and cardiovascular disease (CVD) mortality, CVD incidence, and all-cause mortality? ## Hypothesis The study hypothesized that CTI, an innovative composite marker for metabolic-inflammatory dysregulation, would be associated with CVD mortality, CVD incidence, and all-cause mortality. ## Methods This study analyzed data from 8,679 adults from the National Health and Nutrition Examination Survey (NHANES) 2001-2010, 2015-2018. The CTI was calculated as 0.412* Ln (CRP [mg/L]) + Ln (TG [mg/dl] FPG [mg/dl])/2, and participants were divided into quartiles. Kaplan-Meier curves, cox proportional hazards models, logistic regression analyses, and restricted cubic spline (RCS) were used to assess associations across sex-stratified, age-specific, and glycemic subgroups. ## Results CTI was significantly and positively associated with CVD mortality, total CVD incidence, and all-cause mortality. CTI predicted CVD mortality (HR 2.28) and all-cause mortality (HR 2.14). The CTI index correlated with the risk of total CVD (OR 2.85), congestive heart failure (OR 3.66), coronary heart disease (OR 2.82), angina pectoris (OR 2.85), heart attack (OR 2.59), and stroke (OR 2.86). The association was similar across sexes and age groups, but high CTI was linked to increased CVD risk only in individuals without diabetes mellitus. ## Conclusion Elevated CTI levels are significantly associated with CVD incidence and mortality, suggesting CTI could be a unique predictive marker for CVD risk. ## Limitations The association between high CTI and increased CVD risk was not observed in individuals with diabetes mellitus. ## Verbatim from the abstract > elevated inflammatory index was significantly associated with cardiovascular disease incidence and mortality ## Association of CTI with Cardiovascular Outcomes | Measure | Ratio | | --- | --- | | CVD Mortality (HR) | 2.28 | | All-cause Mortality (HR) | 2.14 | | Total CVD Incidence (OR) | 2.85 | | Congestive Heart Failure (OR) | 3.66 | | Coronary Heart Disease (OR) | 2.82 | | Angina Pectoris (OR) | 2.85 | | Heart Attack (OR) | 2.59 | | Stroke (OR) | 2.86 | *Hazard Ratios (HR) and Odds Ratios (OR) for various cardiovascular outcomes associated with CTI.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | hs-CRP Inflammation Test | Measurement tool | [hs-CRP Inflammation Test](https://magellanlongevity.com/p/142.md) | ## Reference 1. **Evidence: High-sensitivity C-reactive protein** Cardiovasc Diabetol 2025 · [PMID 40750895](https://pubmed.ncbi.nlm.nih.gov/40750895/) · [DOI 10.1186/s12933-025-02835-0](https://doi.org/10.1186/s12933-025-02835-0) > elevated inflammatory index was significantly associated with cardiovascular disease incidence and mortality ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s142.html#page","url":"https://magellanlongevity.com/study/s142.html","name":"Evidence: High-sensitivity C-reactive protein","description":"Higher CTI levels are linked to increased risk of cardiovascular disease and mortality, particularly in individuals without diabetes.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s142.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: High-sensitivity C-reactive protein","item":"https://magellanlongevity.com/study/s142.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s142.html#study","name":"Evidence: High-sensitivity C-reactive protein","headline":"Evidence: High-sensitivity C-reactive protein","datePublished":"2025","isPartOf":{"@type":"Periodical","name":"Cardiovasc Diabetol"},"identifier":"PMID:40750895","url":"https://pubmed.ncbi.nlm.nih.gov/40750895/","sameAs":"https://doi.org/10.1186/s12933-025-02835-0","abstract":"Higher CTI levels are linked to increased risk of cardiovascular disease and mortality, particularly in individuals without diabetes."}]} ``` ## Related on Magellan Longevity - [hs-CRP Inflammation Test](https://magellanlongevity.com/p/142.md) — product graded on this and related evidence - [C-reactive protein and other markers of inflammation in the prediction of cardiovascular…](https://magellanlongevity.com/study/d10733371.md) - [Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women](https://magellanlongevity.com/study/d39216091.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).