--- title: "Evidence: Serum uric acid" description: "Higher serum uric acid levels are linked to increased mortality risk in people with diabetes." url: "https://magellanlongevity.com/study/s151.md" canonical: "https://magellanlongevity.com/study/s151.html" html: "https://magellanlongevity.com/study/s151.html" type: "study" study_key: "s151" journal: "Diabetes Care" year: 2023 pmid: "36490263" doi: "10.2337/dc22-1339" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: Serum uric acid [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: Serum uric acid **HTML version:** https://magellanlongevity.com/study/s151.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s151 ## Citation | Field | Value | | --- | --- | | Journal | Diabetes Care | | Year | 2023 | | PMID | [36490263](https://pubmed.ncbi.nlm.nih.gov/36490263/) | | DOI | [10.2337/dc22-1339](https://doi.org/10.2337/dc22-1339) | | Study key | s151 | ## Takeaway Higher serum uric acid levels are linked to increased mortality risk in people with diabetes. ## The question Is serum uric acid (SUA) level associated with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes? ## Hypothesis The study investigates an association between serum uric acid levels and mortality, implying a potential link. ## Methods This prospective cohort study analyzed data from 7,101 patients with diabetes from the U.S. National Health and Nutritional Examination Survey (NHANES) 1999-2018. Mortality data were linked to national death records through December 31, 2019. Weighted Cox proportional hazards regression models were used to calculate hazard ratios (HRs) for all-cause and CVD mortality. A meta-analysis of 13 additional cohort studies was also performed. ## Results Among NHANES participants, the weighted mean SUA level was 5.7 mg/dL. During 57,926 person-years of follow-up, there were 1,900 deaths, with 674 attributed to CVD. Patients in the highest SUA quintile had an HR of 1.28 for all-cause mortality and 1.41 for CVD mortality compared to those in the lowest SUA quintile. The meta-analysis of 13 cohort studies showed pooled HRs of 1.08 for all-cause mortality and 1.05 for CVD mortality per 1 mg/dL increment of SUA. ## Conclusion Higher serum uric acid levels are associated with increased risks of both all-cause and cardiovascular disease mortality in individuals with diabetes. ## Limitations The study design is observational, which means it can identify associations but not prove causation. The abstract does not explicitly state other limitations. ## Verbatim from the abstract > higher serum uric acid levels were associated with increased risks of all-cause and cardiovascular mortality ## Mortality Risk by Serum Uric Acid Quintile in Diabetes Patients | Measure | Hazard Ratio | | --- | --- | | All-cause mortality (highest vs. lowest quintile) | 1.28 | | CVD mortality (highest vs. lowest quintile) | 1.41 | *Hazard ratios for all-cause and CVD mortality when comparing the highest serum uric acid quintile to the lowest quintile in diabetes patients.* ## Reference 1. **Evidence: Serum uric acid** Diabetes Care 2023 · [PMID 36490263](https://pubmed.ncbi.nlm.nih.gov/36490263/) · [DOI 10.2337/dc22-1339](https://doi.org/10.2337/dc22-1339) > higher serum uric acid levels were associated with increased risks of all-cause and cardiovascular mortality ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s151.html#page","url":"https://magellanlongevity.com/study/s151.html","name":"Evidence: Serum uric acid","description":"Higher serum uric acid levels are linked to increased mortality risk in people with diabetes.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s151.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: Serum uric acid","item":"https://magellanlongevity.com/study/s151.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s151.html#study","name":"Evidence: Serum uric acid","headline":"Evidence: Serum uric acid","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Diabetes Care"},"identifier":"PMID:36490263","url":"https://pubmed.ncbi.nlm.nih.gov/36490263/","sameAs":"https://doi.org/10.2337/dc22-1339","abstract":"Higher serum uric acid levels are linked to increased mortality risk in people with diabetes."}]} ``` ## Related on Magellan Longevity - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).