---
title: "Evidence: Cardiorespiratory fitness (VO2max)"
description: "Regular exercise improves cardiorespiratory fitness and physiological function, enhancing quality of life and promoting life expectancy, though it does…"
url: "https://magellanlongevity.com/study/s152.md"
canonical: "https://magellanlongevity.com/study/s152.html"
html: "https://magellanlongevity.com/study/s152.html"
type: "study"
study_key: "s152"
journal: "Front Biosci"
year: 2018
pmid: "29293447"
doi: "10.2741/4657"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: Cardiorespiratory fitness (VO2max)

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## Citation

| Field | Value |
| --- | --- |
| Journal | Front Biosci |
| Year | 2018 |
| PMID | [29293447](https://pubmed.ncbi.nlm.nih.gov/29293447/) |
| DOI | [10.2741/4657](https://doi.org/10.2741/4657) |
| Study key | s152 |

## Takeaway

Regular exercise improves cardiorespiratory fitness and physiological function, enhancing quality of life and promoting life expectancy, though it does not extend genetically determined lifespan.

## The question

What are the age-related physiological adaptations to regular exercise training, specifically concerning the lung, heart, and skeletal muscles, and how does exercise training impact life expectancy in clinically referred populations?

## Hypothesis

The review aims to emphasize that regular exercise training leads to age-related physiological adaptations in organs involved in oxygen delivery and utilization, and that it is important for promoting life expectancy in clinically referred populations.

## Methods

This is a review article that synthesizes existing evidence regarding cardiorespiratory fitness (VO2max), age-related physiological adaptations to exercise, and the impact of exercise training on life expectancy in clinically referred populations.

## Results

Cardiorespiratory fitness (VO2max) is a strong and independent predictor of all-cause and disease-specific mortality. Regular exercise training induces age-related physiological adaptations in the lung, heart, and skeletal muscles, which are the main organs involved in oxygen delivery and utilization.

## Conclusion

Regular exercise training is crucial for promoting life expectancy in clinically referred populations by inducing physiological adaptations in key organs. While it cannot extend the genetically fixed lifespan, it can improve the quality of life during those years.

## Limitations

The review acknowledges that regular exercise training cannot extend the genetically fixed lifespan.

## Reference

1. **Evidence: Cardiorespiratory fitness (VO2max)**
   Front Biosci 2018 · [PMID 29293447](https://pubmed.ncbi.nlm.nih.gov/29293447/) · [DOI 10.2741/4657](https://doi.org/10.2741/4657)

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## Related on Magellan Longevity

- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).