--- title: "Evidence: NT-proBNP natriuretic peptide" description: "New Canadian guidelines recommend using NT-proBNP before noncardiac surgery for risk assessment and outline specific pre- and post-operative cardiac…" url: "https://magellanlongevity.com/study/s158.md" canonical: "https://magellanlongevity.com/study/s158.html" html: "https://magellanlongevity.com/study/s158.html" type: "study" study_key: "s158" journal: "Can J Cardiol" year: 2016 pmid: "27865641" doi: "10.1016/j.cjca.2016.09.008" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Evidence: NT-proBNP natriuretic peptide [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: NT-proBNP natriuretic peptide **HTML version:** https://magellanlongevity.com/study/s158.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s158 ## Citation | Field | Value | | --- | --- | | Journal | Can J Cardiol | | Year | 2016 | | PMID | [27865641](https://pubmed.ncbi.nlm.nih.gov/27865641/) | | DOI | [10.1016/j.cjca.2016.09.008](https://doi.org/10.1016/j.cjca.2016.09.008) | | Study key | s158 | ## Takeaway New Canadian guidelines recommend using NT-proBNP before noncardiac surgery for risk assessment and outline specific pre- and post-operative cardiac management strategies. ## The question What are the updated Canadian Cardiovascular Society guidelines for perioperative cardiac risk assessment and management in patients undergoing noncardiac surgery? ## Hypothesis The Canadian Cardiovascular Society Guidelines Committee and key Canadian opinion leaders believed there was a need for updated guidelines using the GRADE system for perioperative cardiac risk assessment and management. ## Methods The Canadian Cardiovascular Society Guidelines Committee, along with key Canadian opinion leaders, developed updated guidelines using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system of evidence assessment. ## Results Strong recommendations were made for: 1) measuring BNP or NT-proBNP before surgery in specific patient groups; 2) against several preoperative cardiac tests; 3) against routine acetylsalicylic acid for perioperative cardiac event prevention, with exceptions; 4) against initiating α-agonist or β-blocker within 24 hours before surgery; 5) withholding ACE inhibitor and ARB starting 24 hours before surgery; 6) facilitating smoking cessation before surgery; 7) measuring daily troponin for 48-72 hours after surgery in specific patient groups; and 8) initiating long-term acetylsalicylic acid and statin therapy in patients with postoperative myocardial injury/infarction. ## Conclusion The updated Canadian Cardiovascular Society guidelines provide strong recommendations for perioperative cardiac risk estimation and management, including the use of natriuretic peptides and specific interventions, while advising against certain common practices. ## Limitations The abstract does not explicitly state any limitations of the guideline development process or the recommendations themselves. ## Verbatim from the abstract > measuring NT-proBNP before surgery enhances perioperative cardiac risk estimation ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | NT-proBNP Cardiac Test | — | — | ## Reference 1. **Evidence: NT-proBNP natriuretic peptide** Can J Cardiol 2016 · [PMID 27865641](https://pubmed.ncbi.nlm.nih.gov/27865641/) · [DOI 10.1016/j.cjca.2016.09.008](https://doi.org/10.1016/j.cjca.2016.09.008) > measuring NT-proBNP before surgery enhances perioperative cardiac risk estimation ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s158.html#page","url":"https://magellanlongevity.com/study/s158.html","name":"Evidence: NT-proBNP natriuretic peptide","description":"New Canadian guidelines recommend using NT-proBNP before noncardiac surgery for risk assessment and outline specific pre- and post-operative cardiac…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s158.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Evidence: NT-proBNP natriuretic peptide","item":"https://magellanlongevity.com/study/s158.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s158.html#study","name":"Evidence: NT-proBNP natriuretic peptide","headline":"Evidence: NT-proBNP natriuretic peptide","datePublished":"2016","isPartOf":{"@type":"Periodical","name":"Can J Cardiol"},"identifier":"PMID:27865641","url":"https://pubmed.ncbi.nlm.nih.gov/27865641/","sameAs":"https://doi.org/10.1016/j.cjca.2016.09.008","abstract":"New Canadian guidelines recommend using NT-proBNP before noncardiac surgery for risk assessment and outline specific pre- and post-operative cardiac management strategies."}]} ``` ## Related on Magellan Longevity - [NT-proBNP and mortality across the spectrum of glucose tolerance in the general US…](https://magellanlongevity.com/study/d36344968.md) - [Preoperative NT-proBNP and Cardiovascular Events After Noncardiac Surgery: A Cohort Study](https://magellanlongevity.com/study/d31869834.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).