---
title: "Evidence: retinoic-acid precursor boosts collagen"
description: "Topical retinaldehyde is an effective and safe treatment for photoaged skin."
url: "https://magellanlongevity.com/study/s178.md"
canonical: "https://magellanlongevity.com/study/s178.html"
html: "https://magellanlongevity.com/study/s178.html"
type: "study"
study_key: "s178"
journal: "Dermatology"
year: 1999
pmid: "10473961"
doi: "10.1159/000051379"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Evidence: retinoic-acid precursor boosts collagen

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Evidence: retinoic-acid precursor boosts collagen

**HTML version:** https://magellanlongevity.com/study/s178.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s178

## Citation

| Field | Value |
| --- | --- |
| Journal | Dermatology |
| Year | 1999 |
| PMID | [10473961](https://pubmed.ncbi.nlm.nih.gov/10473961/) |
| DOI | [10.1159/000051379](https://doi.org/10.1159/000051379) |
| Study key | s178 |

## Takeaway

Topical retinaldehyde is an effective and safe treatment for photoaged skin.

## The question

Can topical retinaldehyde improve the signs of photoaged skin?

## Hypothesis

Retinaldehyde, as a precursor to retinoic acid, should have similar beneficial effects on photoaged skin.

## Methods

The study used open and controlled clinical studies. Efficacy was assessed through image analysis of silicone skin replicas.

## Results

Topical retinaldehyde was found to be both efficient and safe.

## Conclusion

Retinaldehyde is an efficient and well-tolerated treatment for improving the signs of photoaging.

## Limitations

The abstract does not specify any limitations of the study.

## Verbatim from the abstract

> Retinaldehyde is efficient and well tolerated for the improvement of the signs of photoaging

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Retinaldehyde Night Serum | Moderate evidence | [Retinaldehyde Night Serum](https://magellanlongevity.com/p/178.md) |

## Reference

1. **Evidence: retinoic-acid precursor boosts collagen**
   Dermatology 1999 · [PMID 10473961](https://pubmed.ncbi.nlm.nih.gov/10473961/) · [DOI 10.1159/000051379](https://doi.org/10.1159/000051379)

   > Retinaldehyde is efficient and well tolerated for the improvement of the signs of photoaging

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## Related on Magellan Longevity

- [Retinaldehyde Night Serum](https://magellanlongevity.com/p/178.md) — product graded on this and related evidence
- [Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin:…](https://magellanlongevity.com/study/d29663701.md)
- [Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of…](https://magellanlongevity.com/study/d21649816.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).