--- title: "Benefits of topical hyaluronic acid for skin quality and signs…" description: "Topical hyaluronic acid improves skin hydration and rejuvenation and can extend the effects of Botulinum toxin type A in reducing wrinkles." url: "https://magellanlongevity.com/study/s184.md" canonical: "https://magellanlongevity.com/study/s184.html" html: "https://magellanlongevity.com/study/s184.html" type: "study" study_key: "s184" journal: "Dermatol Ther" year: 2022 pmid: "36200921" doi: "10.1111/dth.15903" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Benefits of topical hyaluronic acid for skin quality and… **HTML version:** https://magellanlongevity.com/study/s184.html · **In the Magellan app:** https://magellanlongevity.com/#/study/s184 ## Citation | Field | Value | | --- | --- | | Journal | Dermatol Ther | | Year | 2022 | | PMID | [36200921](https://pubmed.ncbi.nlm.nih.gov/36200921/) | | DOI | [10.1111/dth.15903](https://doi.org/10.1111/dth.15903) | | Study key | s184 | ## Takeaway Topical hyaluronic acid improves skin hydration and rejuvenation and can extend the effects of Botulinum toxin type A in reducing wrinkles. ## The question What are the benefits of topical hyaluronic acid (HA) for skin quality and signs of skin aging, and does it enhance the effects of Botulinum toxin type A (BoNTA)? ## Hypothesis Topical hyaluronic acid (HA) is an important component of the extracellular matrix and is expected to have hydration and anti-aging properties. It may also lengthen the duration of BoNTA's effect in reducing wrinkles. ## Methods A literature review was conducted using terms such as HA, hyaluronan, topical, dermatology, cosmetic, aging treatment, exposome, and cosmeceuticals. Additionally, results from a randomized controlled trial (RCT) were presented. In the RCT, subjects were randomized into two groups: one received HA-filler serum twice daily for 24 weeks starting 24 hours after a Botulinum toxin type A (BoNTA) injection, and the control group received only BoNTA. ## Results HA is a key ingredient in cosmeceuticals due to its hydration and anti-aging properties (hygroscopic, rheological, and viscoelastic). Clinical studies indicate that HA is well tolerated and effective as an adjuvant to post-surgical and facial rejuvenation procedures. In the RCT, the HA-filler serum lengthened the duration of BoNTA's effect in reducing wrinkles. ## Conclusion HA-based cosmeceuticals are a noninvasive, effective solution for improving skin hydration and rejuvenation. Topical HA can also extend the duration of BoNTA's wrinkle-reducing effects. ## Limitations The abstract does not explicitly state limitations of the literature review or the randomized controlled trial. ## Verbatim from the abstract > hyaluronic acid is well tolerated and effective for improving skin hydration and rejuvenation ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Hyaluronic Acid Hydrating Serum | Moderate evidence | [Hyaluronic Acid Hydrating Serum](https://magellanlongevity.com/p/184.md) | ## Reference 1. **Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence.** Dermatol Ther 2022 · [PMID 36200921](https://pubmed.ncbi.nlm.nih.gov/36200921/) · [DOI 10.1111/dth.15903](https://doi.org/10.1111/dth.15903) > hyaluronic acid is well tolerated and effective for improving skin hydration and rejuvenation ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/s184.html#page","url":"https://magellanlongevity.com/study/s184.html","name":"Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to…","description":"Topical hyaluronic acid improves skin hydration and rejuvenation and can extend the effects of Botulinum toxin type A in reducing wrinkles.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/s184.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Benefits of topical hyaluronic acid for skin quality and…","item":"https://magellanlongevity.com/study/s184.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/s184.html#study","name":"Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence.","headline":"Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to…","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Dermatol Ther"},"identifier":"PMID:36200921","url":"https://pubmed.ncbi.nlm.nih.gov/36200921/","sameAs":"https://doi.org/10.1111/dth.15903","abstract":"Topical hyaluronic acid improves skin hydration and rejuvenation and can extend the effects of Botulinum toxin type A in reducing wrinkles."}]} ``` ## Related on Magellan Longevity - [Hyaluronic Acid Hydrating Serum](https://magellanlongevity.com/p/184.md) — product graded on this and related evidence - [Effectiveness of topical hyaluronic acid in xerosis cutis treatment in elderly: a…](https://magellanlongevity.com/study/d38829483.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).