---
title: "Regular Supplementation With Resveratrol Improves Bone Mineral…"
description: "Daily resveratrol supplementation may help slow bone loss in the spine and hip of postmenopausal women."
url: "https://magellanlongevity.com/study/x2.md"
canonical: "https://magellanlongevity.com/study/x2.html"
html: "https://magellanlongevity.com/study/x2.html"
type: "study"
study_key: "x2"
journal: "J Bone Miner Res"
year: 2020
pmid: "32564438"
doi: "10.1002/jbmr.4115"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial

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## Citation

| Field | Value |
| --- | --- |
| Journal | J Bone Miner Res |
| Year | 2020 |
| PMID | [32564438](https://pubmed.ncbi.nlm.nih.gov/32564438/) |
| DOI | [10.1002/jbmr.4115](https://doi.org/10.1002/jbmr.4115) |
| Study key | x2 |

## Takeaway

Daily resveratrol supplementation may help slow bone loss in the spine and hip of postmenopausal women.

## The question

Can resveratrol supplementation improve bone health in postmenopausal women?

## Hypothesis

Resveratrol supplementation will improve bone health in postmenopausal women, possibly through circulatory benefits in bone tissue, given its phytoestrogen properties and bone-protective effects observed in rodent models.

## Methods

The RESHAW trial was a 24-month randomized, double-blind, placebo-controlled, two-period crossover intervention. Postmenopausal women received 75 mg of resveratrol twice daily or a placebo. The study evaluated effects on cognition, cerebrovascular function, bone health, cardiometabolic markers, and well-being.

## Results

After 12 months, resveratrol supplementation increased bone density in the lumbar spine by +0.016 g/cm and in the neck of the femur by +0.005 g/cm compared to placebo. This was accompanied by a 7.24% reduction in C-terminal telopeptide type-1 collagen levels. The femoral neck T-score improved by +0.070, reducing the 10-year probability of major and hip fracture risk. The bone-protective benefit was greater in women with poor bone health biomarker status and in those who supplemented with vitamin D plus calcium.

## Conclusion

Regular supplementation with 75 mg of resveratrol twice daily has the potential to slow bone loss in the lumbar spine and femoral neck in postmenopausal women without overt osteoporosis.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> positive effects on bone density in the lumbar spine and femoral neck

## Change in Bone Mineral Density After 12 Months

| Measure | Change in BMD (g/cm) |
| --- | --- |
| Lumbar Spine | 0.016 |
| Femoral Neck | 0.005 |

*Resveratrol supplementation led to an increase in bone mineral density in the lumbar spine and femoral neck.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Trans-Resveratrol | Moderate evidence | [Purovitalis Liposomal Trans-Resveratrol](https://magellanlongevity.com/p/6.md) |

## Reference

1. **Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial**
   J Bone Miner Res 2020 · [PMID 32564438](https://pubmed.ncbi.nlm.nih.gov/32564438/) · [DOI 10.1002/jbmr.4115](https://doi.org/10.1002/jbmr.4115)

   > positive effects on bone density in the lumbar spine and femoral neck

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## Related on Magellan Longevity

- [Purovitalis Liposomal Trans-Resveratrol](https://magellanlongevity.com/p/6.md) — product graded on this and related evidence
- [Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging…](https://magellanlongevity.com/study/resv_sirt1.md)
- [The Potential of Resveratrol to Act as a Caloric Restriction Mimetic Appears to Be…](https://magellanlongevity.com/study/resv_limits.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).