---
title: "Rejuvant, a potential life-extending compound formulation with…"
description: "A supplement called Rejuvant® was associated with an average 8-year reduction in biological age in a small study."
url: "https://magellanlongevity.com/study/x4.md"
canonical: "https://magellanlongevity.com/study/x4.html"
html: "https://magellanlongevity.com/study/x4.html"
type: "study"
study_key: "x4"
journal: "Aging"
year: 2021
pmid: "34847066"
doi: "10.18632/aging.203736"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Rejuvant, a potential life-extending compound formulation…

**HTML version:** https://magellanlongevity.com/study/x4.html · **In the Magellan app:** https://magellanlongevity.com/#/study/x4

## Citation

| Field | Value |
| --- | --- |
| Journal | Aging |
| Year | 2021 |
| PMID | [34847066](https://pubmed.ncbi.nlm.nih.gov/34847066/) |
| DOI | [10.18632/aging.203736](https://doi.org/10.18632/aging.203736) |
| Study key | x4 |

## Takeaway

A supplement called Rejuvant® was associated with an average 8-year reduction in biological age in a small study.

## The question

Can Rejuvant®, an alpha-ketoglutarate based formulation, reduce biological aging in humans?

## Hypothesis

The researchers hypothesized that Rejuvant® could delay and/or reverse biological aging, extending healthspan and lifespan.

## Methods

This was a retrospective analysis of DNA methylation age in 42 individuals. Participants took Rejuvant® for an average of 7 months. DNA methylation testing was performed at baseline and at the end of the treatment period.

## Results

Individuals showed an average decrease in biological aging of 8 years. A large majority of participants experienced a decrease in their biological age. Rejuvant® appeared to offer additional benefits to chronologically and biologically older individuals.

## Conclusion

Rejuvant® is an intriguing candidate to affect human aging, demonstrating a nearly 8-year reversal in biological age in individuals taking it for 4 to 10 months. Further testing, especially in a placebo-controlled design, is required.

## Limitations

The study was a retrospective analysis and lacked a placebo-controlled design, which is noted as a requirement for continued testing.

## Verbatim from the abstract

> individuals showed an average decrease in biological aging of 8 years

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Calcium Alpha-Ketoglutarate (Ca-AKG) | — | — |
| All-in-One Longevity Formulation | Emerging evidence | [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) |

## Reference

1. **Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging**
   Aging 2021 · [PMID 34847066](https://pubmed.ncbi.nlm.nih.gov/34847066/) · [DOI 10.18632/aging.203736](https://doi.org/10.18632/aging.203736)

   > individuals showed an average decrease in biological aging of 8 years

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## Related on Magellan Longevity

- [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) — product graded on this and related evidence
- [Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the…](https://magellanlongevity.com/study/akg_krebs.md)
- [Alpha-Ketoglutarate dietary supplementation to improve health in humans](https://magellanlongevity.com/study/akg_human.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).