--- title: "The Effect of Berberine Supplementation on Glycemic Control and…" description: "Berberine supplementation may help improve blood sugar control and reduce inflammation in adults with metabolic disorders." url: "https://magellanlongevity.com/study/x5.md" canonical: "https://magellanlongevity.com/study/x5.html" html: "https://magellanlongevity.com/study/x5.html" type: "study" study_key: "x5" journal: "Clin Ther" year: 2023 pmid: "38016844" doi: "10.1016/j.clinthera.2023.10.019" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › The Effect of Berberine Supplementation on Glycemic… **HTML version:** https://magellanlongevity.com/study/x5.html · **In the Magellan app:** https://magellanlongevity.com/#/study/x5 ## Citation | Field | Value | | --- | --- | | Journal | Clin Ther | | Year | 2023 | | PMID | [38016844](https://pubmed.ncbi.nlm.nih.gov/38016844/) | | DOI | [10.1016/j.clinthera.2023.10.019](https://doi.org/10.1016/j.clinthera.2023.10.019) | | Study key | x5 | ## Takeaway Berberine supplementation may help improve blood sugar control and reduce inflammation in adults with metabolic disorders. ## The question Does berberine supplementation improve glycemic control and inflammatory biomarkers in individuals with metabolic disorders? ## Hypothesis The study aimed to clarify inconsistent findings from previous meta-analyses regarding berberine's effects on glycemic parameters and inflammatory markers. ## Methods This umbrella meta-analysis systematically searched PubMed, Embase, Web of Science, Scopus, and Google Scholar for relevant meta-analyses published up to April 2023. ## Results Berberine supplementation significantly reduced fasting blood glucose (ES: -0.77 and -0.65), hemoglobin A1C (ES: -0.57), HOMA-IR (ES: -1.04 and -0.71), insulin (ES: -1.00 and -0.63), IL-6 (ES: -1.23), TNF-α (ES: -1.04), and CRP (ES: -0.62 and -1.70). ## Conclusion Berberine supplementation appears effective in improving glycemic parameters and inflammatory markers in adults. ## Limitations The abstract does not explicitly state any limitations of the umbrella meta-analysis itself. ## Verbatim from the abstract > berberine was effective in reducing fasting blood glucose and hemoglobin A1C ## Effect Size of Berberine Supplementation on Glycemic and Inflammatory Markers | Measure | Effect Size (ES) | | --- | --- | | FBG | -0.77 | | HbA1C | -0.57 | | HOMA-IR | -1.04 | | Insulin | -1 | | IL-6 | -1.23 | | TNF-α | -1.04 | | CRP | -1.7 | *Berberine supplementation showed negative effect sizes, indicating reductions in all measured glycemic and inflammatory markers. For markers with multiple effect sizes, the most negative value was chosen for visualization.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Berberine HCl 500 mg (AMPK) | Moderate evidence | [Berberine HCl 500 mg (AMPK)](https://magellanlongevity.com/p/9.md) | ## Reference 1. **The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis** Clin Ther 2023 · [PMID 38016844](https://pubmed.ncbi.nlm.nih.gov/38016844/) · [DOI 10.1016/j.clinthera.2023.10.019](https://doi.org/10.1016/j.clinthera.2023.10.019) > berberine was effective in reducing fasting blood glucose and hemoglobin A1C ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/x5.html#page","url":"https://magellanlongevity.com/study/x5.html","name":"The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic…","description":"Berberine supplementation may help improve blood sugar control and reduce inflammation in adults with metabolic disorders.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/x5.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"The Effect of Berberine Supplementation on Glycemic…","item":"https://magellanlongevity.com/study/x5.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/x5.html#study","name":"The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic Disorders: An Umbrella Meta-analysis","headline":"The Effect of Berberine Supplementation on Glycemic Control and Inflammatory Biomarkers in Metabolic…","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Clin Ther"},"identifier":"PMID:38016844","url":"https://pubmed.ncbi.nlm.nih.gov/38016844/","sameAs":"https://doi.org/10.1016/j.clinthera.2023.10.019","abstract":"Berberine supplementation may help improve blood sugar control and reduce inflammation in adults with metabolic disorders."}]} ``` ## Related on Magellan Longevity - [Berberine HCl 500 mg (AMPK)](https://magellanlongevity.com/p/9.md) — product graded on this and related evidence - [The effect of Berberine on weight loss in order to prevent obesity: A systematic review](https://magellanlongevity.com/study/berberine.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).