CBD

Speaker 1...and that’s where CBD comes in. It modulates the endocannabinoid system, affecting CB1 and CB2 receptors, and also TRP channels, which are involved in pain sensation. For some, it can certainly offer pain relief.

Speaker 2Right, and the connection between chronic pain and aging is critical. We know untreated, persistent pain can accelerate biological aging. For instance, a study in *GeroScience* 2025, PMID 39847262, found painful diabetic neuropathy is linked to accelerated epigenetic aging and telomere shortening compared to painless neuropathy. So, pain management itself can be protective.

Speaker 1Absolutely. But when considering CBD, we have to look at the full picture regarding aging and all-cause mortality. While it can alleviate pain, the long-term impact of its sustained use on these broader health outcomes isn't fully established.

Speaker 2Exactly. The evidence concerning CBD’s direct effect on epigenetic aging or all-cause mortality is still developing. We don't have large-scale, long-term studies definitively showing a positive or negative impact in healthy individuals or even those using it for chronic pain.

Speaker 1It's a balance. For individuals with severe, otherwise untreatable chronic pain, the immediate relief CBD might provide could improve quality of life significantly, potentially offsetting the accelerated aging from the pain itself.

Speaker 2However, potential long-term risks like sedation, falls, or cognitive effects, especially in older adults, need careful consideration. The evidence on these serious harms with long-term CBD use, particularly concerning cardiovascular or GI risks, also remains an area where more robust research is needed.

Speaker 1So, while pain relief can slow biological aging, we don't yet have enough data to say CBD specifically, or its drug class, directly impacts biological aging or all-cause mortality in the long run.