NAD and NMN Supplements: What the Trials Show
Oral NMN and nicotinamide riboside reliably raise blood NAD+ — nicotinamide riboside by 22% to 142% depending on dose. Across randomized trials, grip strength, gait speed, insulin sensitivity and cognition mostly did not follow.
Fisetin — from the newest research
Review in Nutrients (2026) — matched to the evidence-graded products we stockFisetin, a naturally occurring flavonoid, has garnered interest as a potential intervention for age-related diseases due to its anti-inflammatory, antioxidant, and senolytic properties, as demonstrated primarily in preclinical studies.
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$36.45Fisetin Senolytic Capsules
Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction, inflammation, and multiple age-related diseases,…
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📰 Latest from the editorial desk
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Protocols · 2026-09-28Outer Hip Pain: What the Exercise Trials ShowIn the 204-person LEAP trial, eight weeks of load-management education plus hip-abductor exercise left 77.3% of people with gluteal tendinopathy rating themselves at least moderately better, against 58.5% after a corticosteroid injection and 29.4% after waiting; at a year exercise still led on global rating and the injection no longer beat waiting on it, though both still reported less pain than waiting. The outer-hip pain long labelled bursitis is, on imaging, usually a problem of the gluteal tendons and iliotibial band, with bursitis in only a minority. What the exercise consisted of, why the stretches were left out, where the needle and the shockwave device fit, and what a small Glasgow trial found when it compared isometric with isotonic loading.Read the article →Nutraceuticals & Cellular Energizers · 2026-09-28Resveratrol: From Red Wine to RealityWhat the evidence actually shows about resveratrol's healthspan potential, from bone density to knee pain.Read the article →
Research · 2026-09-25Gum Disease and the Rest of the BodyA 2009–2012 CDC survey analysis found periodontitis in 46% of dentate American adults 30 and older. Pooled cohorts of 5.71 million people link it to earlier death, and the count of teeth at 70 tracks survival; a randomized trial found treatment first worsens, then improves arterial function, and the two major blood-sugar trials disagree. A reading of what the mouth’s condition can and cannot yet be said to reveal about the aging body.Read the article →
Protocols · 2026-09-22The Runner's Tendon: What the Trials ShowThe Achilles complaint that ends running seasons turned out not to be an inflammation at all, which may help explain why rest and anti-inflammatories so often disappoint. What has held up in randomized trials is slower and stranger: twelve weeks of heavy, deliberate loading, permission to keep running under a pain-monitoring rule, a cortisone benefit (in a companion patellar trial) that had deteriorated by six months, and a platelet injection that could not beat salt water.Read the article →Nutraceuticals & Cellular Energizers · 2026-09-21Acetyl-L-Carnitine: Narrow Benefits, Not a Longevity PillThe evidence for acetyl-L-carnitine is limited to specific conditions, with no direct support for lifespan extension.Read the article →Protocols · 2026-09-19The First Hour: Creatine and Beet Nitrate Before You MoveCreatine's muscle evidence in adults over 50 comes entirely from trials where everyone was lifting, and dietary nitrate's dose-response study found 4.2 mmol did nothing while 8.4 mmol worked and 16.8 mmol added nothing more. Both fit into breakfast, nitrate sets the timing, antibacterial mouthwash defeats it, and the pair has never been tested together.Read the article →
Research · 2026-09-18Is Loneliness Really as Deadly as Smoking?The poster prices loneliness at fifteen cigarettes a day. The abstracts say something more careful and more useful: disconnection carries mortality-grade risk that is “comparable with well-established risk factors”; yet the feeling of loneliness and the fact of isolation are different exposures that can dissociate under adjustment, and the randomized interventions that work best address neither the calendar nor the living room but the lens.Read the article →
Research · 2026-09-17Aging Beyond the Average: What Repeated Blood Measurements RevealA Science study followed molecular changes in 335 women. Individual trajectories complicate the idea that one average curve describes how everyone ages.Read the article →
Research · 2026-09-17Aging Clocks Need the Right Reference: What Sex-Specific Models ShowA Nature Medicine study examines organ-age models separately by sex. Better references may sharpen research, but a clock score is not a rejuvenation prescription.Read the article →
Effects of Gabapentin and Pregabalin on Calcium Homeostasis: Implications for Physical Rehabilitation of Musculoskeletal Tissues
How do the nerve-pain drugs gabapentin and pregabalin affect bone, muscle and cartilage — and what does that mean for physical rehabilitation?
A narrative review of the mechanism of action of gabapentinoids and the evidence on how chronic treatment affects the musculoskeletal system.
Gabapentin (GBP) and pregabalin (PGB), originally antiepileptics and now first-line for neuropathic pain (and often prescribed off-label for migraine and back pain), produce analgesia by selectively binding…
Clinicians guiding rehabilitation should weigh the potential musculoskeletal complications of chronic gabapentinoid use, since these drugs may interfere with the calcium signaling that bone, muscle and…
🛰️ Longevity Tech
🧪 Home Lab & DiagnosticsStrong evidenceApoB: The Cholesterol Number Your Panel Probably Didn't PrintOne particle, one measurement, and a cleaner line to risk than the LDL-C most labs report by default.
⌚ Wearables & SensorsStrong evidenceYour Ring Says 47 Minutes of Deep Sleep. The Lab Says Maybe.Consumer sleep trackers are good at telling sleep from wake and mediocre at staging it. The validation studies are unusually blunt about which is which.
🧪 Home Lab & DiagnosticsMixed evidenceLp(a): Test It Once, Then Watch the Drug PipelineIt is genetically fixed, it raises risk, nothing on the shelf lowers it meaningfully — and the drugs that do are in phase 3.
🔥 Recovery, Light & HeatMixed evidenceRed Light Therapy: The Skin Data Is Real, the Longevity Claims Aren'tPhotobiomodulation has decent randomised evidence for skin and pain, a biphasic dose curve, and a marketing layer far ahead of the biology.
🚀 Frontier TechPreclinical only evidencePartial Reprogramming: The Best Idea in Aging Biology, and Its Cliff EdgeTurn a cell partway back toward youth and stop before it forgets what it is. Everything hard about this is in the word 'partway'.
🧰 Clinical tools, free to use
🍽️ Recipes for healthy aging
Nitric oxideBeetroot and arugula are two of the richest dietary sources of nitrate — the raw material your body converts into nitric oxide, the molecule that relaxes and widens blood vessels.
Nitric oxideWatermelon is the richest everyday food source of L-citrulline — the amino acid your body converts into L-arginine, the raw material your blood vessels use to make nitric oxide.
Nitric oxideSpinach sits alongside arugula and beets at the top of the dietary-nitrate list, and a controlled trial found nitrate-rich spinach raised nitric-oxide status and improved endothelial function.
Nitric oxideA small, concentrated hit of beet juice about two hours before training — the timing and dose most closely matching the nitrate research.
Nitric oxideRaw arugula is one of the highest-nitrate foods there is — and pesto is the rare recipe that keeps a large pile of it completely uncooked.
Nitric oxideTwo different routes to nitric oxide in one glass: nitrate from beets, and cocoa flavanols, whose vascular effect was traced specifically to epicatechin.
Nitric oxideA vivid magenta dip that turns a full serving of nitrate-rich beets into something you will actually finish.
Nitric oxideCelery is quietly one of the higher-nitrate vegetables, and eating it raw and crunchy is the best way to keep that nitrate intact.
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🛍️ The evidence-graded shop
Behaviors first. The strongest evidence for a longer life is about how you move, eat and sleep — none of the products below has trial evidence anywhere near that of walking, strength and balance work, which is why our free 12-week program comes before the shop. Every product carries a grade earned from human research — with the studies linked in place of star ratings. Commissions never reorder the picks; our disclosure and grading method are public.
Get the Evidence-Based Longevity Starter Guide
A free, plain-language PDF on how to weigh human evidence, prioritize measurements, and read a supplement label. Plus an occasional, no-hype research digest.