Urolithin A is a gut-derived metabolite that triggers mitophagy — recycling worn-out mitochondria. Here is the human evidence, the benefits, and the best way to get it.
See the urolithin A evidence →Your gut bacteria convert ellagitannins from pomegranate, walnuts and berries into urolithin A — but only some people produce meaningful amounts. Urolithin A activates mitophagy, the cellular clean-up that clears damaged mitochondria, and human trials show improvements in muscle strength and endurance markers. Because production from food is so variable, a standardized supplement (Mitopure) is the reliable route. See the mitochondrial research.
Linked to its mechanism and PubMed studies.
Restores mitochondrial quality control declining with age. Research relevant to this mechanism is indexed on PubMed and linked below; it describes…
Feeds gut production of pro-longevity urolithins. Research relevant to this mechanism is indexed on PubMed and linked below; it describes the…
Urolithin A activates mitophagy — the recycling of damaged mitochondria — and human trials show benefits for muscle strength and endurance.
Randomized human trials show measurable improvements in muscle and mitochondrial markers, which is stronger evidence than most longevity compounds have. See the linked studies.
Indirectly — your gut bacteria make it from ellagitannins in pomegranate, walnuts and berries, but many people produce little or none, which is why a standardized supplement is more reliable.
Human trials commonly use about 500 mg/day of urolithin A. Check with your physician before starting.
Mitophagy, muscle trials, and where to get a standardized dose.
See the urolithin A evidence →