Every product below is graded on the strength of real human and mechanistic research and linked to its primary PubMed citations — independent of affiliate commissions. 65 products.
22 PubMed citations
Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum…
23 PubMed citations
Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training…
22 PubMed citations
In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the…
23 PubMed citations
Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom…
20 PubMed citations
In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering…
18 PubMed citations
In non-alcoholic fatty liver disease (NAFLD/MASLD), multiple meta-analyses of randomized trials…
20 PubMed citations
For weight and metabolic syndrome, meta-analyses of randomized trials indicate that green tea…
19 PubMed citations
In human trials, standardized olive leaf extract has most consistently produced modest reductions…
23 PubMed citations
The best-supported clinical use of ALA is for symptomatic diabetic peripheral neuropathy:…
27 PubMed citations
In human trials CoQ10 has been studied mainly as an adjunct in cardiovascular disease: the…
20 PubMed citations
In human research, urolithin A supplementation is safe and bioavailable and improves markers of…
19 PubMed citations
In small randomized trials, magnesium-L-threonate improved composite cognition versus placebo in…
21 PubMed citations
Meta-analyses of controlled trials indicate that beta-alanine produces a small but statistically…
21 PubMed citations
The best human evidence concerns eye health in aging: in the landmark AREDS2 randomized trial,…
25 PubMed citations
Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on…
19 PubMed citations
Pooled analyses of randomized trials indicate oral magnesium lowers blood pressure by a small…
21 PubMed citations
In the large COSMOS randomized trial of older adults, daily cocoa extract did not significantly…
18 PubMed citations
CD38 activity rises with age and drives the tissue decline of NAD+ that is linked to mitochondrial…
18 PubMed citations
Small human trials report that about 3 g of glycine before bedtime improves subjective sleep…
17 PubMed citations
In randomized trials and meta-analyses, myo-inositol (often combined with D-chiro-inositol) has…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
24 PubMed citations
Meta-analyses of randomized trials indicate that carnosine or beta-alanine supplementation…
25 PubMed citations
In human trials, Pycnogenol has improved flow-mediated dilation and other measures of endothelial…
21 PubMed citations
Randomized trials and meta-analyses indicate that grape seed extract can modestly lower blood…
22 PubMed citations
In human trials, hesperidin or hesperidin-rich orange juice has improved endothelial function and…
23 PubMed citations
Human trials and meta-analyses consistently show that oral betaine lowers fasting and…
18 PubMed citations
In human aging and health, PQQ is studied mainly for cognitive function, mitochondrial and energy…
26 PubMed citations
Randomized trials and meta-analyses report modest benefits on cognition in mild cognitive…
21 PubMed citations
In human trials, both L-5-MTHF and folic acid raise blood folate and lower total homocysteine, an…
25 PubMed citations
Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction,…
21 PubMed citations
Preclinical studies consistently show that luteolin reduces neuroinflammation and can ameliorate…
16 PubMed citations
In humans, blood ergothioneine levels tend to fall with age, particularly after 60, and multiple…
25 PubMed citations
In human research, the ellagitannin-derived metabolite urolithin A has improved muscle strength,…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
19 PubMed citations
Human trials indicate that concentrated broccoli-sprout sulforaphane can modestly lower fasting…
20 PubMed citations
In small randomized and crossover trials, tart cherry juice or concentrate has modestly increased…
20 PubMed citations
Older and mostly small randomized trials, pooled in meta-analyses, suggest that L-carnitine given…
24 PubMed citations
Multiple randomized controlled trials and meta-analyses report that saffron (commonly about 20-30…
25 PubMed citations
The individual ingredients carry uneven levels of human evidence. Lutein and zeaxanthin are the…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
23 PubMed citations
Observational cohorts consistently link higher dietary and urinary polyphenol (and flavonoid)…
19 PubMed citations
A landmark 2023 study reported that taurine declines with age in mice, monkeys, and humans and…
26 PubMed citations
Several of NOVOS Core's ingredients have genuine, though mostly early-stage, human or animal…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
26 PubMed citations
In human health, the best-supported effects of resveratrol come from randomized trials and…
22 PubMed citations
In model organisms (yeast, worms, flies and mice) spermidine induces autophagy and extends…
18 PubMed citations
In randomized trials and their meta-analyses in type 2 diabetes, berberine has produced…
17 PubMed citations
Large randomized trials and meta-analyses give a mixed picture. In generally healthy,…
34 PubMed citations
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been…
17 PubMed citations
Randomized trials show that oral glutathione supplementation can genuinely raise body stores — a…
24 PubMed citations
Evidence on glucosamine for aging-related joint health is genuinely mixed: in the landmark 3-year…
16 PubMed citations
In small clinical trials, mostly pilot and open-label studies plus one randomized…
24 PubMed citations
The strongest human evidence is indication-specific: a Cochrane review of 31 trials (8,672…
14 PubMed citations
In a randomized, double-blind proof-of-concept trial in overweight or obese insulin-resistant…
21 PubMed citations
Randomized trials and meta-analyses indicate that inulin-type fructans reliably increase stool…
24 PubMed citations
Meta-analyses of randomized trials show that beetroot juice and dietary nitrate lower blood…
18 PubMed citations
Across randomized trials and several meta-analyses, oral PEA has been associated with reductions…
17 PubMed citations
The best-studied use of Boswellia serrata relevant to human aging is knee and hand osteoarthritis,…
21 PubMed citations
Across human studies, MSM has been evaluated mainly for osteoarthritis, exercise recovery, and…
22 PubMed citations
The most firmly established human benefit of lithium is a reduction in suicide and all-cause…
24 PubMed citations
Evidence on glucosamine and chondroitin for osteoarthritis is large but genuinely mixed. The…
25 PubMed citations
The evidence for glucosamine and chondroitin in human osteoarthritis is genuinely mixed. The…
21 PubMed citations
MSM has been studied chiefly for knee osteoarthritis, where small, short-term randomized trials…
25 PubMed citations
In human health, phosphatidylcholine's most encouraging evidence is in ulcerative colitis, where…