GlyNAC pairs the amino acid glycine with the cysteine donor N-acetylcysteine (NAC) to supply both rate-limiting building blocks of glutathione (GSH), the cell's master antioxidant. Glutathione synthesis falls with age, driving oxidative stress, mitochondrial dysfunction and impaired mitophagy.
In aging mice, GlyNAC corrected glutathione deficiency and extended lifespan by ~24% while reversing mitochondrial and genomic-damage hallmarks. In randomized and pilot human trials in older adults, 12-16 weeks of GlyNAC improved glutathione status, oxidative stress, mitochondrial function, inflammation, strength and several aging hallmarks. Human evidence comes from small, short trials on biomarkers and function rather than long-term mortality outcomes.
Peer-reviewed studies on the active compound — citations link to PubMed.
“GlyNAC supplementation improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function and multiple hallmarks of aging in older adults.”
“GlyNAC supplementation increased length of life in mice by 24% while correcting glutathione deficiency and multiple defects of aging.”
Research describes the active mechanism and is not a claim about this specific product.
Slightly reduces coronary mortality and events. Research relevant to this mechanism is…
Counters sarcopenia, frailty and bone loss in aging. Research relevant to this mechanism…
Counters oxidative stress accumulating with age. Research relevant to this mechanism is…
Maintains immune competence across the lifespan. Research relevant to this mechanism is…
Yes — its active compound is linked to 2 peer-reviewed studies, summarized and cited above.
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Dietary supplements and devices are generally well tolerated but are not a substitute for medical care. Talk to your physician before starting, especially if you take medication or have a health condition.