Can GlyNAC supplementation increase lifespan and improve age-associated defects in mice?
The Journals of Gerontology: Series A · 2022 · PMID 35268089
GlyNAC supplementation extended the lifespan of mice by 24% and corrected several age-related cellular defects.
The question
Can GlyNAC supplementation increase lifespan and improve age-associated defects in mice?
What they tested
GlyNAC supplementation will increase longevity by correcting glutathione deficiency, oxidative stress, and mitochondrial dysfunction.
How they did it
The study evaluated the effect of GlyNAC supplementation versus a placebo in C57BL/6J mice. Researchers measured the length of life and assessed age-associated glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy, nutrient-sensing, and genomic damage in the heart, liver, and kidneys.
What they found
Mice supplemented with GlyNAC lived 24% longer than control mice. GlyNAC supplementation also improved or corrected impaired glutathione synthesis, glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy, nutrient-sensing, and genomic damage.
| Control Mice | 100 | |
|---|---|---|
| GlyNAC Supplemented Mice | 124 |
Mice receiving GlyNAC supplementation lived 24% longer than control mice.
What it means
GlyNAC supplementation can increase lifespan and improve multiple age-associated defects in mice, providing a proof-of-concept for its potential as a nutritional supplement to enhance lifespan and healthspan.
Limitations
This study was conducted in mice, and the findings may not directly translate to humans. Further investigation is warranted.
The paper at a glance
| Title | GlyNAC supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage |
|---|---|
| Journal | The Journals of Gerontology: Series A |
| Year | 2022 |
| PMID | 35268089 ↗ |
| Topic | Immunity, inflammation & resilience |
| DOI | Not recorded in our database — use the PubMed record above. |
Read the source: PubMed record (authors, abstract, full citation) ↗
Where Magellan uses this paper
This citation sits behind the evidence grade on the pages below. Grades are set from the research and are independent of affiliate commissions.
GlyNAC (Glycine + N-Acetylcysteine)
In small clinical trials, mostly pilot and open-label studies plus one randomized placebo-controlled trial of 24 older adults from the same laboratory, GlyNAC supplementation corrected glutathione deficiency and improved markers of oxidative stress, mitochondrial function, inflammation, insulin resistance, muscle…
GlyNAC is a nutritional supplement combining two amino acids, glycine and N-acetylcysteine (NAC, a…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record.
Magellan Longevity. (2026). Can GlyNAC supplementation increase lifespan and improve age-associated defects in mice? [Plain-English summary of The Journals of Gerontology: Series A 2022, PMID 35268089]. Magellan Longevity. https://magellanlongevity.com/study/glynac_mice.html@misc{magellan_glynac_mice,
title = {Can GlyNAC supplementation increase lifespan and improve age-associated defects in mice?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/glynac_mice.html}},
note = {Plain-English summary of PubMed PMID 35268089; The Journals of Gerontology: Series A 2022. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
}https://magellanlongevity.com/study/glynac_mice.htmlRelated studies in the Magellan library
- Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione…The Journals of Gerontology: Series A · 2022 · PMID 35975308
- GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress…Clin Transl Med · 2021 · PMID 33783984
- Cocoa Flavanol Supplementation and ExerciseSports Med · 2018 · PMID 29299877
- Mechanisms and applications of the anti-inflammatory effects of photobiomodulationAIMS Biophysics · 2017 · PMID 28748217
- Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older…JAMA Netw Open · 2022 · PMID 35050355
- Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial…Cell Rep Med · 2022 · PMID 35584623
All 17 Magellan summaries on immunity, inflammation & resilience →
Prefer the interactive version? Open this summary in the Magellan app → · Browse all 314 study summaries →