M MagellanLONGEVITY

Gut–Immune Axis

Inulin

In one paragraph

Inulin, graded Moderate-evidence on Magellan — one of the best-studied prebiotic fibers: reliable for constipation relief, with small (~1 kg) average weight effects and small LDL/triglyceride reductions whose certainty is rated low to very low. Some trials report no benefit, prebiotics have failed to improve irritable bowel syndrome symptoms, and inulin commonly causes gas, bloating and flatulence at higher doses.

Source: Nutrients 2021, PMID 34579112 ↗ · Evidence-graded supplements · Research map · Study write-up · evidence confidence: high

Inulin is a prebiotic fiber fermented into butyrate and other short-chain fatty acids that feed the gut lining and beneficial Bifidobacteria. Fiber broadly tracks with lower mortality.

Prebiotic fiber fermented into butyrate; feeds Bifidobacteria.

Research-backed interactions

increases Bifidobacteria / butyrate

Inulin increased gut Bifidobacteria and improved HOMA-IR after adjustment in adults at risk of type 2 diabetes.

Nutrients, 2021 · PubMed 34579112

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Frequently asked

How does Inulin relate to longevity?

Inulin is a prebiotic fiber fermented into butyrate and other short-chain fatty acids that feed the gut lining and beneficial Bifidobacteria. Fiber broadly tracks with lower mortality.

How is Inulin related to Bifidobacteria / butyrate?

Inulin increased gut Bifidobacteria and improved HOMA-IR after adjustment in adults at risk of type 2 diabetes.