Nicotinamide Mononucleotide, graded Moderate-evidence on Magellan — oral NMN reliably raises blood NAD⁺ and has been well tolerated in trials up to about 900–1,250 mg/day. Functional benefits so far are modest and population-specific (muscle insulin sensitivity in prediabetic women, aerobic capacity, walking speed, sleep quality), several meta-analyses are null for glucose, lipids and muscle mass, and no trial shows effects on aging, disease prevention, or lifespan.
Source: GeroScience 2022, PMID 36482258 ↗ · Evidence-graded supplements · Research map · Study write-up · evidence confidence: high
NMN (nicotinamide mononucleotide) is a direct precursor to NAD⁺, a coenzyme that declines with age. Here are the NMN products we grade highest on evidence and quality, with the research behind them.
Browse NAD⁺ & NMN products →NAD⁺ powers cellular energy and DNA repair and falls with age; NMN is one step away from NAD⁺ in the salvage pathway. When choosing an NMN supplement, the things that matter are purity (third-party tested, ≥99%), dose (trials typically use 250–900 mg/day), and delivery (some use liposomal forms). Read the NAD⁺ research for the human trials.
Each links to its monograph and PubMed citations.
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly…
The best NMN is one that is third-party tested for purity (≥99%), dosed in the studied range (250–900 mg/day), and from a transparent brand. Each NMN product here is graded on evidence and links to its research.
NMN reliably raises NAD⁺ in humans in trials; effects on hard aging outcomes are still being studied. The product pages link to the current human evidence.
Both raise NAD⁺. NR (nicotinamide riboside) has more human trial data; NMN is one step closer to NAD⁺. Evidence is still evolving for both.
Human trials commonly use 250–900 mg per day. Start low and discuss with your physician, especially if you take medication.
NMN, NR and NAD⁺ activators, graded on the evidence.
Browse NAD⁺ & NMN products →