Omega-3 EPA/DHA Fish Oil, as summarised by Magellan (Nat Aging 2025, PMID 39900648) — the main result was null: major cardiovascular events occurred in 386 omega-3 participants versus 419 on placebo (hazard ratio 0.92, 95% CI 0.80 to 1.06), and there was no reduction in cancer. Fish-oil fats nudged biological-aging clocks in one trial, but the heart-disease record is genuinely mixed.
Source: Nat Aging 2025, PMID 39900648 ↗ · Evidence-graded supplements · Full write-up · Research map · evidence confidence: high
Long-chain omega-3s EPA and DHA are among the best-supported nutrients for cardiovascular and brain aging. Here is the evidence, and how to know your Omega-3 Index.
Browse omega-3 & testing →EPA and DHA are anti-inflammatory fatty acids your body cannot make efficiently. A higher Omega-3 Index (the EPA+DHA percentage in red blood cells) tracks with better cardiovascular and brain aging — and you can measure it at home. Oily fish is the best food source; a quality fish-oil or algae supplement closes the gap.
Linked to mechanism and PubMed citations.
Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides (roughly 15% at higher doses) and modestly…
In prospective cohort studies and pooled analyses spanning dozens of cohorts, higher blood levels of EPA + DHA have been consistently associated…
Higher omega-3 levels track with lower cardiovascular and all-cause mortality in large cohorts; trial effects are modest but consistent for heart health.
Many studies use roughly 1–2 g/day of combined EPA+DHA; aim for an Omega-3 Index of 8–12%.
It is the percentage of EPA+DHA in your red blood cell membranes — a measurable marker you can test at home.
Algae oil is a vegan EPA/DHA source; both raise the Omega-3 Index. Choose a third-party-tested product.