Senolytics target senescent cells that accumulate with age and drive inflammation. Here is the science, and the senolytic supplements you can actually buy — graded on the research.
See the top senolytic →As we age, some cells stop dividing but refuse to die — “senescent” cells that secrete inflammatory signals (the SASP) and accelerate tissue aging. Senolytics are compounds that selectively push these cells to clear. The most studied natural senolytics are the flavonoids fisetin and quercetin, both under active human investigation. See the broader senolytics & senescence research.
Linked to their mechanisms and PubMed studies.
Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction, inflammation, and multiple age-related diseases,…
Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on the order of 2–3 mmHg—most apparent at doses of…
Senolytics are compounds that selectively clear senescent “zombie” cells — cells that have stopped dividing but secrete inflammatory signals that drive aging.
Fisetin is the most-studied natural senolytic flavonoid, found in strawberries, and is under active clinical investigation for clearing senescent cells. In the NIA Interventions Testing Program's 2024 mouse study (GeroScience 2024;46:795-816), fisetin did not clear senescent cells: p16Ink4a mRNA rose with age in kidney, brain and liver, but neither fisetin schedule lowered p16-positive cells versus age-matched controls — senescence assays run by the Robbins lab, and the authors note whole-tissue p16 mRNA is an imperfect senescence marker and that plasma fisetin was not reliably detectable.
Early human trials are underway and mechanistic and animal data are strong, but large long-term human outcome trials are still limited. Each product page links to the current evidence.
Many protocols use intermittent (“hit-and-run”) dosing rather than daily use. Discuss any senolytic regimen with your physician.
Fisetin, quercetin and the senescence research behind them.
See the top senolytic →