MAGELLAN LONGEVITY
Muscle & brain · evidence-graded

Creatine: muscle, brain, and healthy aging

Creatine monohydrate is one of the most-researched supplements on Earth — and increasingly studied for muscle preservation and cognition in aging. Here is the evidence.

Browse creatine & muscle support →
Home › Creatine

Why creatine matters for aging

Creatine monohydrate buffers cellular energy (ATP). Beyond strength, randomized trials show it helps older adults preserve muscle mass and may support cognition under stress. It is cheap, safe, and exceptionally well studied — a rare combination in the longevity space.

Creatine supplements, graded

Linked to mechanism and PubMed citations.

Creatine Monohydrate

3 PubMed-linked studies

Counters sarcopenia, frailty and bone loss in aging. Research relevant to this mechanism is indexed on PubMed and linked below; it describes the…

Educational information, not medical advice. Supplements are not intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement, especially if you are pregnant, nursing, or taking medication.

Frequently asked questions

Is creatine good for aging?

Yes — trials show creatine plus resistance training helps older adults preserve muscle and strength, and it is being studied for brain aging.

What is the creatine dose?

A common protocol is 3–5 g/day of creatine monohydrate, with or without an optional loading phase.

Is creatine safe?

Creatine monohydrate is one of the most-studied supplements and is well tolerated in healthy adults; check with your physician if you have kidney disease.

Does creatine help the brain?

Some trials show cognitive benefits, especially under sleep deprivation or in vegetarians; evidence is promising but still developing.

See the creatine evidence

Muscle, strength, and cognition in aging.

Browse creatine & muscle support →