Pomegranate Ellagitannin Extract is a longevity product whose active basis is precursor to urolithins, mitophagy. Provides ellagitannins converted to mitophagy-activating urolithins. It is positioned for resale to the growing healthspan-focused consumer market.
Feeds gut production of pro-longevity urolithins. Research relevant to this mechanism is indexed on PubMed and linked below; it describes the mechanism rather than this specific product.
Peer-reviewed studies on the active compound — citations link to PubMed.
“urolithin A is safe and can improve mitochondrial biomarkers in elderly patients”
“LDL-cholesterol and oxidized LDL dose-dependently decreased, correlated with urolithin production”
“Ellagitannins and their gut-derived metabolites, the urolithins, modify gene expression in colon”
“Compared with the placebo group, POMx supplement significantly reduced the score of DAS28 (P<0.001) which could be related to the decrease in swollen (P<0.001) and tender joints (P=0.001) count, pain intensity (P=0.003) and ESR levels (P= 0.03).”
“Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention.”
“This evidence-based review highlighted the potential of pomegranate extract being used for treating bone loss in osteoporosis, osteoarthritis and rheumatoid arthritis.”
Research describes the active mechanism and is not a claim about this specific product.
Slightly reduces coronary mortality and events. Research relevant to this mechanism is…
Counters sarcopenia, frailty and bone loss in aging. Research relevant to this mechanism…
Counters oxidative stress accumulating with age. Research relevant to this mechanism is…
Maintains immune competence across the lifespan. Research relevant to this mechanism is…
Yes — its active compound is linked to 6 peer-reviewed studies, summarized and cited above.
You can buy it on Amazon via the link above; Magellan earns a small affiliate commission at no extra cost to you, which does not affect the evidence grade.
Dietary supplements and devices are generally well tolerated but are not a substitute for medical care. Talk to your physician before starting, especially if you take medication or have a health condition.