SimPure Reverse Osmosis System, graded Emerging-evidence on Magellan — RO also takes magnesium and calcium out along with everything else, and drinking-water magnesium is inversely associated with coronary mortality in observational studies. No numeric effect size is reported for SimPure Reverse Osmosis System in Magellan's graded summary.
Source: Journal of Cellular Biochemistry 2017, PMID 28643849 ↗ · Air, Water & Sleep Systems · How Magellan grades evidence · Study write-up · evidence confidence: low
A reverse osmosis (RO) system purifies drinking water by forcing it under pressure through a semipermeable membrane whose extremely small pores block dissolved salts, metals, and most organic molecules while allowing water molecules through. This physical barrier can remove or greatly reduce contaminants such as arsenic, lead, nitrate, fluoride, disinfection byproducts (trihalomethanes), per- and polyfluoroalkyl substances (PFAS), and microplastics, and US regulators named RO among the best available point-of-use technologies under the 2024 national PFAS drinking-water standards. RO is one of the high-pressure membrane technologies recognized for broad-spectrum contaminant reduction and is commonly deployed as a point-of-use system at a kitchen tap.
The health rationale for RO rests on evidence that the contaminants it removes are linked to disease: long-term exposure to trihalomethanes is associated with bladder cancer, drinking-water nitrate with colorectal cancer, inorganic arsenic with cardiovascular disease and several cancers, lead with cardiovascular mortality and impaired child cognition, and PFAS with immune, metabolic, and reproductive effects, often at levels below current regulatory limits. Bench and field studies show point-of-use RO cuts contaminant concentrations by one to two orders of magnitude and removes metals and PFAS that basic carbon filters miss. Honest caveats: most exposure–disease links are observational, no trial shows that installing a home RO system improves health outcomes, RO strips beneficial minerals and wastes some water, and its value scales with local water quality. This literature describes the exposures and their removal in general, not this specific commercial product's performance.
Peer-reviewed studies on the active compound — citations link to PubMed.
“The predominant source resulting in measurable human exposure to heavy metals is the consumption of contaminated drinking water, with consequences including cardiovascular, neuronal and renal injury and risk of cancer and diabetes.”
“heterogeneity in contaminant exposures across sociodemographic subgroups and neighborhoods”
“This suggests a statistically significant positive correlation between long-term exposure to chlorinated drinking water and an increased risk of bladder cancer.”
“These findings strengthen the hypothesis that the risk of bladder cancer is increased with long-term exposure to disinfection byproducts at levels currently observed in many industrialized countries.”
“trihalomethanes, the most common class of disinfection by-products, have been linked to bladder cancer”
“Cardiovascular disease (CVD) in association with iAs exposure has been examined in a number of studies and provides a basis for evaluating a reference dose (RfD) for assessing potential non-cancer health risks of arsenic exposure.”
Research describes the active mechanism and is not a claim about this specific product.
Research on the biomarker this device tracks - blood-oxygen saturation and nocturnal…
The compounds this filter targets - trihalomethanes and related disinfection by-products…
Research links low indoor humidity to impaired airway mucociliary clearance and weakened…
Observational cohort studies and meta-analyses link higher magnesium intake—including…
Yes — its active compound is linked to 34 peer-reviewed studies, summarized and cited above.
You can buy it on Amazon via the link above; Magellan earns a small affiliate commission at no extra cost to you, which does not affect the evidence grade.
Dietary supplements and devices are generally well tolerated but are not a substitute for medical care. Talk to your physician before starting, especially if you take medication or have a health condition.