Broccoli Sprout Sulforaphane, as summarised by Magellan (Cancer Prev Res (Phila) 2014, PMID 24913818) — importantly, bioavailability held steady across the full 12 weeks, and the benzene effect was larger in people with a functioning GSTT1 gene. Broccoli-sprout sulforaphane switches on the cell's antioxidant defense system, but the human trials range from encouraging to flatly null.
Source: Cancer Prev Res (Phila) 2014, PMID 24913818 ↗ · Evidence-graded supplements · Full write-up · Research map · evidence confidence: high
Sulforaphane, concentrated in broccoli sprouts, activates the Nrf2 pathway that turns up your cells' own antioxidant and detox enzymes. Here is the evidence and how to get it.
Browse sulforaphane products →Sulforaphane is made when you chew raw broccoli — especially broccoli sprouts, the richest source. It activates Nrf2, the master switch for your cells’ built-in antioxidant and detoxification enzymes, which is a more durable strategy than swallowing antioxidants directly.
Linked to mechanism and PubMed citations.
Human trials indicate that concentrated broccoli-sprout sulforaphane can modestly lower fasting blood glucose and glycated hemoglobin, most clearly…
It activates the Nrf2 pathway, upregulating your cells' own antioxidant and detox enzymes.
Broccoli sprouts are the richest natural source; a standardized supplement with active myrosinase gives a more consistent dose.
Trials vary; many use the equivalent of tens of milligrams of sulforaphane or glucoraphanin daily.
Human trials show it raises antioxidant-defense markers; longer outcome data are still developing.
Sulforaphane and your built-in antioxidant defenses.
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