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Nrf2 antioxidant defense · evidence-graded

Sulforaphane: switching on Nrf2 antioxidant defense

Sulforaphane, concentrated in broccoli sprouts, activates the Nrf2 pathway that turns up your cells' own antioxidant and detox enzymes. Here is the evidence and how to get it.

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What sulforaphane does

Sulforaphane is made when you chew raw broccoli — especially broccoli sprouts, the richest source. It activates Nrf2, the master switch for your cells’ built-in antioxidant and detoxification enzymes, which is a more durable strategy than swallowing antioxidants directly.

Sulforaphane supplements, graded

Linked to mechanism and PubMed citations.

Broccoli Sprout Sulforaphane

3 PubMed-linked studies

Supports glucose control and antioxidant defenses with aging. Research relevant to this mechanism is indexed on PubMed and linked below; it…

Educational information, not medical advice. Supplements are not intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement, especially if you are pregnant, nursing, or taking medication.

Frequently asked questions

What does sulforaphane do?

It activates the Nrf2 pathway, upregulating your cells' own antioxidant and detox enzymes.

Broccoli sprouts vs a supplement?

Broccoli sprouts are the richest natural source; a standardized supplement with active myrosinase gives a more consistent dose.

What is the sulforaphane dose?

Trials vary; many use the equivalent of tens of milligrams of sulforaphane or glucoraphanin daily.

Does sulforaphane work?

Human trials show it raises antioxidant-defense markers; longer outcome data are still developing.

Explore the Nrf2 science

Sulforaphane and your built-in antioxidant defenses.

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