Reprogramming, plasma exchange, senolytics, gene therapy and AI drug discovery — what is in humans and what is still a slide deck.
| Story | Evidence | Worth buying | Skip |
|---|---|---|---|
| Partial Reprogramming: The Best Idea in Aging Biology, and Its Cliff Edge | Preclinical only | Nothing here yet - there is nothing to buy, and no human in-vivo result exists to buy it on. | Skip anyone selling reprogramming, rejuvenation clinics included: the human evidence base is one regulatory clearance to start a trial. |
| Plasma Exchange: Young Blood Without the Young Blood | Mixed | Nothing you can buy - every credible use of this procedure is a clinical indication or a registered trial. | Skip any clinic selling plasma exchange or young-donor plasma as an anti-aging service; the FDA has said outright there is no proven benefit for that purpose. |
| Senolytics Finished Real Trials. Here's What They Showed. | Early | Nothing you can buy - the discoverers of this drug class explicitly decline to endorse consumer use. | Skip anything sold as a 'senolytic supplement'; the label borrows credibility from trials that used different doses and did not test the claim. |
| Follistatin, Klotho, Telomerase: Gene Therapy You Can Buy on an Island | Preclinical only | Nothing you can buy - and the FDA says that being charged for these products outside a clinical trial means you are likely being deceived. | Skip medical tourism for gene therapy entirely; the vector's own toxicity record is why real trials carry monitoring committees. |
| AI Found a Fibrosis Drug and Put It in Humans. Aging Is Next on the Slide Deck. | Early | Nothing you can buy - the only AI-discovered candidates in humans are investigational drugs in disease trials. | Skip any product or clinic invoking 'AI-discovered' as a quality signal; it describes how a molecule was found, not whether it works. |
| Neurotech for Aging Brains: Implants, Ultrasound, and a Lot of Electrodes | Mixed | Nothing you can buy - no consumer headset has been tested, blinded, against a cognitive outcome in older adults. | Skip devices citing the 40 Hz mouse paper; the human trial built to test cognition missed all three primary endpoints. |
Turn a cell partway back toward youth and stop before it forgets what it is. Everything hard about this is in the word 'partway'.
Dilute the plasma of an old animal and something improves. Doing it to people is a real trial question with early, small answers.
Dasatinib plus quercetin and fisetin have moved out of mice and into small human studies, with results that are more interesting than triumphant.
Clinics offshore will inject a gene into you today. What comes back is a press release, not a result.
Generative models have produced clinical candidates. Whether they can produce an aging drug is a different and harder question.
Brain-computer interfaces are real and are not for aging. The non-invasive stimulation aisle is where the aging claims live, and it is noisy.
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