Spermidine is a naturally occurring polyamine present in foods such as wheat germ, aged cheese, mushrooms and soy. Polyamines are essential for cell growth and are found in every cell of the body, though tissue levels decline with age.
Spermidine is one of the few compounds shown to extend lifespan in yeast, flies, worms and mice. Its principal mechanism is the induction of autophagy — the cell's recycling program that clears damaged proteins and organelles. Autophagy is a central node in aging biology, and spermidine-triggered autophagy has been linked to cardioprotection and improved memory in animal models.
Peer-reviewed studies on the active compound — citations link to PubMed.
“The difference in mortality risk between the highest and lowest spermidine intake was statistically comparable to being 5.7 years younger.”
“Administration of spermidine, a natural polyamine, markedly extended the lifespan of yeast, flies and worms, and human immune cells, by triggering autophagy.”
“Oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function.”
“exploratory analyses indicated possible beneficial effects on verbal memory and inflammation”
“Mechanistically, spermidine suppressed Nos2 expression by inhibiting the NF-κB pathway in astrocytes, thereby alleviating neuropathic pain.”
“However, the specific protective mechanism of SPD in osteoarthritis (OA) remains unclear.”
Research describes the active mechanism and is not a claim about this specific product.
Slightly reduces coronary mortality and events. Research relevant to this mechanism is…
Counters sarcopenia, frailty and bone loss in aging. Research relevant to this mechanism…
Counters oxidative stress accumulating with age. Research relevant to this mechanism is…
Maintains immune competence across the lifespan. Research relevant to this mechanism is…
Yes — its active compound is linked to 6 peer-reviewed studies, summarized and cited above.
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Dietary supplements and devices are generally well tolerated but are not a substitute for medical care. Talk to your physician before starting, especially if you take medication or have a health condition.