NOVOS Core (multi-ingredient formula) has 8 documented interactions in Magellan’s curated dataset, covering Anticoagulants (blood thinners), Antiplatelet drugs, Antidepressants (SSRIs and SNRIs), Quinolone antibiotics, Tetracycline antibiotics, Bisphosphonates (osteoporosis drugs) and others. Each entry below gives the mechanism as the cited reference states it, the direction the risk runs, how serious that reference treats it, and what to actually do about it — which is, in every case, a conversation with the clinician or pharmacist who manages the prescription rather than a decision you make alone.
What it is. NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen compounds intended to target several biological 'hallmarks of aging. ' Its ingredients include calcium alpha-ketoglutarate (a Krebs-cycle metabolite), the senolytic flavonoid fisetin, pterostilbene (a methylated resveratrol analog), glycine, glucosamine sulfate, magnesium malate, L-theanine, Rhodiola rosea, a microdose of lithium, hyaluronic acid, ginger, and vitamin C.
Where it sits on the evidence. Magellan grades the supplement itself as Emerging evidence. That grade is about whether it works, not about whether it is safe alongside your medication — the two questions are independent, and this page answers only the second.
Products this covers: NOVOS Core All-In-One Sachets.
How the risks cluster. The entries split across 6 different mechanisms — bleeding risk; absorption and timing; opposing; additive; drug levels; additive sedation — and they are not managed the same way: an absorption problem is fixed by separating the doses in time, an additive or opposing effect is not.
Safety and efficacy are separate questions, and this page only answers the first. For the second, the study Magellan’s coverage of NOVOS Core rests on is:
“Regular glucosamine use was associated with 15% lower all-cause mortality (HR 0.85) and 18% lower cardiovascular mortality among 495,077 UK Biobank participants — observational, so it cannot prove cause.”
A strong result does not make a supplement safe alongside your prescription, and a documented interaction does not mean the supplement does not work. Magellan grades those two things separately, and neither grade moves for a commission.
Magellan’s Medication Safety Check runs entirely on your device — type the medicines you take and it flags every documented interaction in this dataset. Nothing you type is sent anywhere.
Open the Medication Safety Check →Ginger has the strongest documented evidence in this blend: case reports include elevated INR and bleeding on phenprocoumon and a fatal GI bleed on dabigatran, and it is recommended to stop ginger 2 weeks before surgery. Glucosamine sulfate and pterostilbene each separately carry documented or plausible anticoagulant-potentiating/antiplatelet effects, compounding the concern for anyone on warfarin, DOACs, or antiplatelet therapy.
Medicines in this group include: Warfarin (Coumadin, Jantoven), Apixaban (Eliquis), Rivaroxaban (Xarelto), Dabigatran (Pradaxa), Edoxaban (Savaysa), Heparin (Lovenox, Enoxaparin), Acenocoumarol (Sintrom), Aspirin (Asa, Bayer aspirin) and 4 more.
Rhodiola's MAO-inhibiting activity has a documented case of tachyarrhythmia when combined with a prescription antidepressant.
Medicines in this group include: Sertraline (Zoloft), Fluoxetine (Prozac), Escitalopram (Lexapro), Citalopram (Celexa), Paroxetine (Paxil), Venlafaxine (Effexor), Duloxetine (Cymbalta), Desvenlafaxine (Pristiq) and 3 more.
Magnesium reduces absorption of oral bisphosphonates (e.g., alendronate) and forms insoluble complexes with tetracycline and quinolone antibiotics, reducing their effectiveness; dosing should be separated by 2+ hours.
Medicines in this group include: Ciprofloxacin (Cipro), Levofloxacin (Levaquin), Moxifloxacin (Avelox), Doxycycline (Vibramycin), Minocycline (Minocin), Tetracycline (Sumycin), Alendronate (Fosamax), Risedronate (Actonel) and 2 more.
High-dose vitamin C can interfere with the activity of several chemotherapy agents by counteracting their oxidative mechanism; patients on active cancer treatment should consult their oncologist before use.
Medicines in this group include: Methotrexate (Trexall, Otrexup), Tamoxifen (Nolvadex), Cisplatin, Doxorubicin (Adriamycin), Vincristine (Oncovin), Bortezomib (Velcade), Cyclophosphamide (Cytoxan).
Ginger may cause additive blood-glucose-lowering effects with insulin or oral glucose-lowering medications; clinical relevance in humans is not fully established but caution and glucose monitoring are reasonable.
Medicines in this group include: Metformin (Glucophage, Fortamet), Insulin (Humalog, Novolog), Glipizide (Glucotrol), Glyburide (Diabeta, Glynase), Glimepiride (Amaryl), Sitagliptin (Januvia), Empagliflozin (Jardiance), Dapagliflozin (Farxiga) and 5 more.
Calcium reduces absorption of levothyroxine and quinolone antibiotics (e.g., ciprofloxacin); dosing should be separated by several hours.
Medicines in this group include: Ciprofloxacin (Cipro), Levofloxacin (Levaquin), Moxifloxacin (Avelox), Levothyroxine (Synthroid, Levoxyl), Liothyronine (Cytomel), Desiccated thyroid (Armour thyroid, Np thyroid).
These drug classes are documented to raise lithium blood levels at prescription lithium-carbonate dosing by reducing renal clearance. This product contains only a microdose of lithium, so the magnitude of risk is far lower than with prescription lithium, but the mechanism is the same and worth flagging for users on these medications.
Medicines in this group include: Lithium (Lithobid, Eskalith).
L-theanine may increase drowsiness when combined with prescription sedative-hypnotics; patients on these medications should discuss use with their provider.
Medicines in this group include: Trazodone (Desyrel), Alprazolam (Xanax), Lorazepam (Ativan), Clonazepam (Klonopin), Diazepam (Valium), Zolpidem (Ambien), Eszopiclone (Lunesta), Temazepam (Restoril) and 1 more.
These are the warning signs that go with the medication classes on this page. They are general safety-netting, not a prediction that any supplement will cause them.
If something feels seriously wrong, do not wait for an appointment. Call 911 (US) or your local emergency number.
Severity describes the interaction as the cited reference frames it, not how a specific person will react. A “minor” entry in someone with kidney disease, on five other drugs, can matter more than a “major” one in someone on nothing else.
This is a curated set of interactions with citations — not an exhaustive pharmacology database. An interaction that is absent here has not been ruled out; it may simply not be documented in the references Magellan curates from. Supplements are also not batch-tested for identity or contamination the way prescription drugs are, so what is on the label is a claim rather than a guarantee. And most of these entries come from case reports and mechanistic work rather than randomized trials, which is exactly why the sensible response is a pharmacist review rather than either alarm or dismissal.
22 documented interactions across 17 supplements.
43 documented interactions across 24 supplements.
7 documented interactions across 6 supplements.
7 documented interactions · shares a drug class with NOVOS Core.
5 documented interactions · shares a drug class with NOVOS Core.
3 documented interactions · shares a drug class with NOVOS Core.
4 documented interactions · shares a drug class with NOVOS Core.
A–Z of every supplement and drug class in this dataset, plus how to read an interaction.
What the research actually shows, graded independently of affiliate commissions.
Not without checking with the prescriber or pharmacist first. Magellan's dataset grades this as a major interaction: Ginger has the strongest documented evidence in this blend: case reports include elevated INR and bleeding on phenprocoumon and a fatal GI bleed on dabigatran, and it is recommended to stop ginger 2 weeks before surgery. Glucosamine sulfate and pterostilbene each separately carry documented or plausible anticoagulant-potentiating/antiplatelet effects, compounding the concern for anyone on warfarin, DOACs, or antiplatelet therapy. (Source: Ginger.)
The cited reference specifies an interval: Dosing should be separated by 2+ hours. Confirm the exact timing with the pharmacist who dispensed the medication, because it depends on the formulation.
8 interactions are documented in Magellan's curated dataset: 1 major, 5 moderate, 2 minor. They cover Anticoagulants (blood thinners), Antiplatelet drugs, Antidepressants (SSRIs and SNRIs), Quinolone antibiotics, Tetracycline antibiotics. Absence from this list is not proof of safety — it means no interaction is documented in the references we curate from.