DaVinci Labs Phyto Benefits has 3 documented interactions in Magellan’s curated dataset, covering Anticoagulants (blood thinners), Antiplatelet drugs, Chemotherapy and cancer therapy, Statins (cholesterol medications), Immunosuppressants, Sedatives and sleep medications and others. Each entry below gives the mechanism as the cited reference states it, the direction the risk runs, how serious that reference treats it, and what to actually do about it — which is, in every case, a conversation with the clinician or pharmacist who manages the prescription rather than a decision you make alone.
What it is. Polyphenols are a large and diverse family of naturally occurring compounds produced by plants, characterized by multiple phenolic rings, and are abundant in fruits, vegetables, tea, coffee, cocoa, red wine, olive oil, whole grains, and legumes. Major subclasses include flavonoids (such as flavanols, flavonols, anthocyanins, and isoflavones), phenolic acids, stilbenes (such as resveratrol), and lignans.
Where it sits on the evidence. Magellan grades the supplement itself as Moderate evidence. That grade is about whether it works, not about whether it is safe alongside your medication — the two questions are independent, and this page answers only the second.
Products this covers: DaVinci Labs Phyto Benefits.
How the risks cluster. The entries split across 2 different mechanisms — bleeding risk; drug levels — and they are not managed the same way, so read each one rather than assuming a single rule covers all of them.
Safety and efficacy are separate questions, and this page only answers the first. For the second, the study Magellan’s coverage of DaVinci Labs Phyto Benefits rests on is:
“Across 281 RCTs (17,126 participants), polyphenol supplements modestly improved cardiometabolic markers—catechins lowered systolic blood pressure ~1.6 mmHg, anthocyanins improved lipids, curcumin improved glucose handling.”
A strong result does not make a supplement safe alongside your prescription, and a documented interaction does not mean the supplement does not work. Magellan grades those two things separately, and neither grade moves for a commission.
Magellan’s Medication Safety Check runs entirely on your device — type the medicines you take and it flags every documented interaction in this dataset. Nothing you type is sent anywhere.
Open the Medication Safety Check →This is a mixed polyphenol/flavonoid blend; multiple polyphenol classes (resveratrol-like stilbenes, quercetin-like flavonols, and related bioflavonoids such as rutin) independently inhibit platelet aggregation and/or potentiate warfarin in documented case reports, so a blend combining several such compounds carries an additive bleeding-risk concern with blood thinners.
Medicines in this group include: Warfarin (Coumadin, Jantoven), Apixaban (Eliquis), Rivaroxaban (Xarelto), Dabigatran (Pradaxa), Edoxaban (Savaysa), Heparin (Lovenox, Enoxaparin), Acenocoumarol (Sintrom), Aspirin (Asa, Bayer aspirin) and 4 more.
Quercetin-type flavonoids have been shown to substantially increase tamoxifen bioavailability in preclinical studies, and resveratrol-type stilbenes have estrogen-receptor-activating properties; patients on hormone therapy or with hormone-sensitive cancers should discuss use with their oncologist.
Medicines in this group include: Methotrexate (Trexall, Otrexup), Tamoxifen (Nolvadex), Cisplatin, Doxorubicin (Adriamycin), Vincristine (Oncovin), Bortezomib (Velcade), Cyclophosphamide (Cytoxan).
Individual polyphenols in this class of supplement (resveratrol-type and quercetin-type compounds) have documented in-vitro/in-vivo inhibition of these cytochrome P450 enzymes; combining several such polyphenols in one blend raises the theoretical risk of additively altered blood levels for CYP3A4/2C9/2D6-metabolized prescription drugs.
Medicines in this group include: Atorvastatin (Lipitor), Simvastatin (Zocor), Rosuvastatin (Crestor), Lovastatin (Mevacor, Altoprev), Pravastatin (Pravachol), Pitavastatin (Livalo), Fluvastatin (Lescol), Cyclosporine (Neoral, Sandimmune) and 20 more.
These are the warning signs that go with the medication classes on this page. They are general safety-netting, not a prediction that any supplement will cause them.
If something feels seriously wrong, do not wait for an appointment. Call 911 (US) or your local emergency number.
Severity describes the interaction as the cited reference frames it, not how a specific person will react. A “minor” entry in someone with kidney disease, on five other drugs, can matter more than a “major” one in someone on nothing else.
This is a curated set of interactions with citations — not an exhaustive pharmacology database. An interaction that is absent here has not been ruled out; it may simply not be documented in the references Magellan curates from. Supplements are also not batch-tested for identity or contamination the way prescription drugs are, so what is on the label is a claim rather than a guarantee. And most of these entries come from case reports and mechanistic work rather than randomized trials, which is exactly why the sensible response is a pharmacist review rather than either alarm or dismissal.
22 documented interactions across 17 supplements.
9 documented interactions across 9 supplements.
9 documented interactions across 9 supplements.
2 documented interactions · shares a drug class with DaVinci Labs Phyto Benefits.
2 documented interactions · shares a drug class with DaVinci Labs Phyto Benefits.
3 documented interactions · shares a drug class with DaVinci Labs Phyto Benefits.
3 documented interactions · shares a drug class with DaVinci Labs Phyto Benefits.
A–Z of every supplement and drug class in this dataset, plus how to read an interaction.
What the research actually shows, graded independently of affiliate commissions.
Not without checking with the prescriber or pharmacist first. Magellan's dataset grades this as a moderate interaction: This is a mixed polyphenol/flavonoid blend; multiple polyphenol classes (resveratrol-like stilbenes, quercetin-like flavonols, and related bioflavonoids such as rutin) independently inhibit platelet aggregation and/or potentiate warfarin in documented case reports, so a blend combining several such compounds carries an additive bleeding-risk concern with blood thinners. (Source: Quercetin.)
3 interactions are documented in Magellan's curated dataset: 2 moderate, 1 minor. They cover Anticoagulants (blood thinners), Antiplatelet drugs, Chemotherapy and cancer therapy, Statins (cholesterol medications), Immunosuppressants. Absence from this list is not proof of safety — it means no interaction is documented in the references we curate from.