Several longevity supplements lower blood pressure in their own right, and several are handled by the same liver enzymes as common antihypertensives. Neither fact makes them off-limits; both make home blood-pressure readings worth taking for a couple of weeks after any change.
Below is every interaction Magellan documents for this class — 15 entries across 14 supplements, each with the mechanism as the cited reference states it, how serious that reference treats it, and where to take the question next.
One caveat on how to weigh them. 4 of the 15 entries below are marked class-level caution: the source flags a broad group of drugs that share a metabolic pathway — usually CYP3A4 — rather than reporting a finding about a named medicine. Those are weaker than the entries that name a specific drug, and they are labelled so you can tell the difference rather than being quietly padded in.
Magellan’s Medication Safety Check runs entirely on your device — type the medicines you take and it flags every documented interaction in this dataset. Nothing you type is sent anywhere.
Open the Medication Safety Check →Fish oil can itself lower blood pressure slightly, so combining with antihypertensive drugs may increase the blood-pressure-lowering effect.
Berberine has its own blood-pressure- and heart-rate-lowering effects and is processed via liver enzyme pathways shared with drugs like losartan; combined use may compound blood-pressure lowering or alter drug levels.
CoQ10 can itself lower blood pressure, so taking it with antihypertensive drugs may add to the blood-pressure-lowering effect.
High doses of green tea have been shown to reduce blood levels, and therefore the effectiveness, of nadolol, a beta-blocker used for high blood pressure and heart problems.
At higher doses resveratrol can systemically inhibit cytochrome P450 enzymes, potentially attenuating or altering the activity of drugs that rely on these pathways; a 2020 literature review flags this as a real but understudied interaction risk.
Pomegranate appears to lower blood pressure on its own; combined with antihypertensive drugs it may push blood pressure too low.
Hesperidin may have blood-pressure-lowering effects and could interact with calcium channel blockers like diltiazem and verapamil, both via additive blood pressure lowering and altered drug absorption.
Grape seed extract inhibits the CYP3A4 enzyme in vitro and may alter blood levels of drugs metabolized through this pathway; clinical relevance has not been determined.
Laboratory experiments show olive leaf extract can increase the blood-pressure-lowering effect of antihypertensive drugs; clinical significance in humans has not yet been established.
Saffron may lower blood pressure on its own; combined with blood pressure medication it could cause blood pressure to drop too low.
These blood pressure medications can raise lithium blood levels by reducing renal excretion; documented for therapeutic-dose lithium, extrapolated cautiously to low-dose orotate.
Beetroot/dietary nitrate itself has a blood-pressure-lowering effect; combined with antihypertensive medications it may cause additive blood pressure lowering, warranting monitoring, especially at supplement (vs. dietary) doses.
Beet may alter how quickly the liver metabolizes CYP3A4-substrate drugs, potentially changing their effectiveness or side effects.
Individual polyphenols in this class of supplement (resveratrol-type and quercetin-type compounds) have documented in-vitro/in-vivo inhibition of these cytochrome P450 enzymes; combining several such polyphenols in one blend raises the theoretical risk of additively altered blood levels for CYP3A4/2C9/2D6-metabolized prescription drugs.
Carnosine may itself lower blood pressure; combining it with blood pressure-lowering medication could cause blood pressure to drop excessively.
Medicines in this group include: Amlodipine (Norvasc), Diltiazem (Cardizem, Tiazac), Verapamil (Calan, Verelan), Nifedipine (Procardia, Adalat), Hydrochlorothiazide (Hctz, Microzide), Chlorthalidone (Thalitone), Indapamide (Lozol), Furosemide (Lasix), Bumetanide (Bumex), Torsemide (Demadex), Spironolactone (Aldactone), Eplerenone (Inspra), Amiloride (Midamor), Triamterene (Dyrenium), Lisinopril (Prinivil, Zestril), Enalapril (Vasotec), Ramipril (Altace), Captopril (Capoten), Benazepril (Lotensin), Losartan (Cozaar), Valsartan (Diovan), Olmesartan (Benicar), Irbesartan (Avapro), Candesartan (Atacand), Telmisartan (Micardis), Metoprolol (Lopressor, Toprol), Atenolol (Tenormin), Propranolol (Inderal), Carvedilol (Coreg), Nadolol (Corgard), Bisoprolol (Zebeta), Labetalol (Trandate).
Brand names are listed in brackets after the generic ingredient. If the name on your bottle is not here, the generic name on the label almost always is — and the Medication Safety Check accepts either.
Severity describes the interaction as the cited reference frames it, not how a specific person will react. A “minor” entry in someone with kidney disease, on five other drugs, can matter more than a “major” one in someone on nothing else.
This is a curated set of interactions with citations — not an exhaustive pharmacology database. An interaction that is absent here has not been ruled out; it may simply not be documented in the references Magellan curates from. Supplements are also not batch-tested for identity or contamination the way prescription drugs are, so what is on the label is a claim rather than a guarantee. And most of these entries come from case reports and mechanistic work rather than randomized trials, which is exactly why the sensible response is a pharmacist review rather than either alarm or dismissal.
3 documented interactions in total.
5 documented interactions in total.
4 documented interactions in total.
4 documented interactions in total.
2 documented interactions in total.
4 documented interactions in total.
3 documented interactions in total.
2 documented interactions in total.
2 documented interactions in total.
4 documented interactions in total.
4 documented interactions in total.
3 documented interactions in total.
3 documented interactions in total.
1 documented interaction in total · covered on the hub.
Blood thinners · Diabetes medications · Statins · Cancer treatment · Antibiotics · Immunosuppressants · Diuretics · Other drug classes
Back to the full supplement–drug safety hub → · The evidence-graded supplement guide →
Omega-3 (EPA/DHA fish oil), Berberine, CoQ10 / ubiquinol, Green tea EGCG extract, Resveratrol, Pomegranate ellagitannins, Hesperidin (citrus flavonoid), Grape seed extract, Olive leaf extract (oleuropein), Saffron extract, Low-dose lithium (lithium orotate), Beetroot and dietary nitrate, DaVinci Labs Phyto Benefits, Carnosine — 15 documented entries in total (0 major, 7 moderate, 8 minor). Each entry on this page names the reference it came from.
In this dataset the class includes Amlodipine, Diltiazem, Verapamil, Nifedipine, Hydrochlorothiazide, Chlorthalidone and others. Brand names are mapped to their generic ingredient inside the Medication Safety Check, so typing the name on your bottle works.
Usually not. Most entries here call for one of three things: separating the doses by a few hours, monitoring a lab value or a home reading for a couple of weeks, or a prescriber-led dose adjustment. The decision belongs to the clinician who manages the prescription — what this page is for is making sure the conversation happens before you start rather than after something goes wrong.