Low-dose lithium (lithium orotate) has 4 documented interactions in Magellan’s curated dataset, covering ACE inhibitors and ARBs, Prescription lithium, Thiazide diuretics, NSAID pain relievers. Each entry below gives the mechanism as the cited reference states it, the direction the risk runs, how serious that reference treats it, and what to actually do about it — which is, in every case, a conversation with the clinician or pharmacist who manages the prescription rather than a decision you make alone.
What it is. Lithium orotate is a salt of the trace element lithium and orotic acid, sold as a low-dose dietary supplement that typically provides only a few milligrams of elemental lithium per serving—far below the doses of lithium carbonate (roughly 150-1,200 mg) used as a prescription mood stabilizer. Lithium occurs naturally in drinking water, grains and vegetables and is ingested in variable trace amounts through the diet.
Where it sits on the evidence. Magellan grades the supplement itself as Emerging evidence, with a typical studied dose of 5 mg elemental lithium per capsule (about 1/25th-1/40th of a psychiatric dose). That grade is about whether it works, not about whether it is safe alongside your medication — the two questions are independent, and this page answers only the second.
Products this covers: Lithium Orotate (5 mg).
How the risks cluster. The entries split across 2 different mechanisms — drug levels; additive serotonergic effect — and they are not managed the same way, so read each one rather than assuming a single rule covers all of them.
Safety and efficacy are separate questions, and this page only answers the first. For the second, the study Magellan’s coverage of Low-dose lithium rests on is:
“We find an inverse correlation between drinking water lithium concentrations and all-cause mortality in 18 neighbouring Japanese municipalities (1,206,174 individuals)... a comparably low concentration of lithium extends lifespan of C. elegans.”
A strong result does not make a supplement safe alongside your prescription, and a documented interaction does not mean the supplement does not work. Magellan grades those two things separately, and neither grade moves for a commission.
Magellan’s Medication Safety Check runs entirely on your device — type the medicines you take and it flags every documented interaction in this dataset. Nothing you type is sent anywhere.
Open the Medication Safety Check →These blood pressure medications can raise lithium blood levels by reducing renal excretion; documented for therapeutic-dose lithium, extrapolated cautiously to low-dose orotate.
Medicines in this group include: Lisinopril (Prinivil, Zestril), Enalapril (Vasotec), Ramipril (Altace), Captopril (Capoten), Benazepril (Lotensin), Losartan (Cozaar), Valsartan (Diovan), Olmesartan (Benicar) and 4 more.
Thiazide and loop diuretics decrease lithium clearance by the kidneys, increasing lithium levels and toxicity risk.
Medicines in this group include: Lithium (Lithobid, Eskalith), Hydrochlorothiazide (Hctz, Microzide), Chlorthalidone (Thalitone), Indapamide (Lozol).
NSAIDs reduce renal clearance of lithium, raising blood lithium levels and toxicity risk. This is well-established for prescription lithium carbonate; there is no dedicated interaction study for 5mg lithium orotate, but because it delivers the same lithium ion, the same caution is reasonable at a lower magnitude.
Medicines in this group include: Lithium (Lithobid, Eskalith), Ibuprofen (Advil, Motrin), Naproxen (Aleve, Naprosyn), Meloxicam (Mobic), Celecoxib (Celebrex), Diclofenac (Voltaren, Cataflam), Indomethacin (Indocin).
Lithium itself has serotonergic activity; combining with other serotonergic medications carries a documented risk of serotonin syndrome, again established at prescription dosing.
Medicines in this group include: Lithium (Lithobid, Eskalith).
These are the warning signs that go with the medication classes on this page. They are general safety-netting, not a prediction that any supplement will cause them.
If something feels seriously wrong, do not wait for an appointment. Call 911 (US) or your local emergency number.
Severity describes the interaction as the cited reference frames it, not how a specific person will react. A “minor” entry in someone with kidney disease, on five other drugs, can matter more than a “major” one in someone on nothing else.
This is a curated set of interactions with citations — not an exhaustive pharmacology database. An interaction that is absent here has not been ruled out; it may simply not be documented in the references Magellan curates from. Supplements are also not batch-tested for identity or contamination the way prescription drugs are, so what is on the label is a claim rather than a guarantee. And most of these entries come from case reports and mechanistic work rather than randomized trials, which is exactly why the sensible response is a pharmacist review rather than either alarm or dismissal.
15 documented interactions across 14 supplements.
43 documented interactions across 24 supplements.
5 documented interactions across 4 supplements.
8 documented interactions · shares a drug class with Low-dose lithium.
5 documented interactions · shares a drug class with Low-dose lithium.
5 documented interactions · shares a drug class with Low-dose lithium.
4 documented interactions · shares a drug class with Low-dose lithium.
The mechanism and the research behind the compound itself.
A–Z of every supplement and drug class in this dataset, plus how to read an interaction.
What the research actually shows, graded independently of affiliate commissions.
Not without checking with the prescriber or pharmacist first. Magellan's dataset grades this as a moderate interaction: These blood pressure medications can raise lithium blood levels by reducing renal excretion; documented for therapeutic-dose lithium, extrapolated cautiously to low-dose orotate. (Source: 7 Common Drugs Linked To Dangerous Lithium Interactions.)
4 interactions are documented in Magellan's curated dataset: 4 moderate. They cover ACE inhibitors and ARBs, Prescription lithium, Thiazide diuretics, NSAID pain relievers. Absence from this list is not proof of safety — it means no interaction is documented in the references we curate from.
Magellan lists the typical studied dose as: 5 mg elemental lithium per capsule (about 1/25th-1/40th of a psychiatric dose). Dose matters for interactions — several of the entries on this page describe effects that only appear at supplemental rather than dietary intakes.