Hesperidin (citrus flavonoid) has 3 documented interactions in Magellan’s curated dataset, covering Anticoagulants (blood thinners), Antiplatelet drugs, Calcium channel blockers, Chemotherapy and cancer therapy, Immunosuppressants. Each entry below gives the mechanism as the cited reference states it, the direction the risk runs, how serious that reference treats it, and what to actually do about it — which is, in every case, a conversation with the clinician or pharmacist who manages the prescription rather than a decision you make alone.
What it is. Hesperidin is a flavanone glycoside (a citrus bioflavonoid) found abundantly in oranges, lemons, and other citrus fruits, where it is concentrated in the peel and white pith. After ingestion it is hydrolyzed by gut microbiota to its aglycone hesperetin, which is absorbed and circulates mainly as glucuronide and sulfate metabolites.
Where it sits on the evidence. Magellan grades the supplement itself as Moderate evidence, with a typical studied dose of ~500 mg/day isolated, or via hesperidin-enriched juice. That grade is about whether it works, not about whether it is safe alongside your medication — the two questions are independent, and this page answers only the second.
Products this covers: Hesperidin Citrus Flavonoid.
How the risks cluster. The entries split across 2 different mechanisms — bleeding risk; drug levels — and they are not managed the same way, so read each one rather than assuming a single rule covers all of them.
Safety and efficacy are separate questions, and this page only answers the first. For the second, the study Magellan’s coverage of Hesperidin rests on is:
“hesperidin protected individuals from postprandial endothelial dysfunction”
A strong result does not make a supplement safe alongside your prescription, and a documented interaction does not mean the supplement does not work. Magellan grades those two things separately, and neither grade moves for a commission.
Magellan’s Medication Safety Check runs entirely on your device — type the medicines you take and it flags every documented interaction in this dataset. Nothing you type is sent anywhere.
Open the Medication Safety Check →Hesperidin (commonly studied combined with diosmin, as in venous-insufficiency products) may slow blood clotting and interfere with anticoagulant metabolism; a Health Canada safety review linked diosmin/hesperidin products to increased bleeding risk, including cases in patients on anticoagulants, prompting mandated label warnings.
Medicines in this group include: Warfarin (Coumadin, Jantoven), Apixaban (Eliquis), Rivaroxaban (Xarelto), Dabigatran (Pradaxa), Edoxaban (Savaysa), Heparin (Lovenox, Enoxaparin), Acenocoumarol (Sintrom), Aspirin (Asa, Bayer aspirin) and 4 more.
Hesperidin may have blood-pressure-lowering effects and could interact with calcium channel blockers like diltiazem and verapamil, both via additive blood pressure lowering and altered drug absorption.
Medicines in this group include: Amlodipine (Norvasc), Diltiazem (Cardizem, Tiazac), Verapamil (Calan, Verelan), Nifedipine (Procardia, Adalat).
Hesperidin may inhibit P-glycoprotein drug transporters, potentially increasing absorption and blood levels of medications that are P-gp substrates.
Medicines in this group include: Methotrexate (Trexall, Otrexup), Tamoxifen (Nolvadex), Cisplatin, Doxorubicin (Adriamycin), Vincristine (Oncovin), Bortezomib (Velcade), Cyclophosphamide (Cytoxan), Cyclosporine (Neoral, Sandimmune) and 4 more.
These are the warning signs that go with the medication classes on this page. They are general safety-netting, not a prediction that any supplement will cause them.
If something feels seriously wrong, do not wait for an appointment. Call 911 (US) or your local emergency number.
Severity describes the interaction as the cited reference frames it, not how a specific person will react. A “minor” entry in someone with kidney disease, on five other drugs, can matter more than a “major” one in someone on nothing else.
This is a curated set of interactions with citations — not an exhaustive pharmacology database. An interaction that is absent here has not been ruled out; it may simply not be documented in the references Magellan curates from. Supplements are also not batch-tested for identity or contamination the way prescription drugs are, so what is on the label is a claim rather than a guarantee. And most of these entries come from case reports and mechanistic work rather than randomized trials, which is exactly why the sensible response is a pharmacist review rather than either alarm or dismissal.
22 documented interactions across 17 supplements.
15 documented interactions across 14 supplements.
9 documented interactions across 9 supplements.
3 documented interactions · shares a drug class with Hesperidin.
2 documented interactions · shares a drug class with Hesperidin.
2 documented interactions · shares a drug class with Hesperidin.
8 documented interactions · shares a drug class with Hesperidin.
A–Z of every supplement and drug class in this dataset, plus how to read an interaction.
What the research actually shows, graded independently of affiliate commissions.
Not without checking with the prescriber or pharmacist first. Magellan's dataset grades this as a moderate interaction: Hesperidin (commonly studied combined with diosmin, as in venous-insufficiency products) may slow blood clotting and interfere with anticoagulant metabolism; a Health Canada safety review linked diosmin/hesperidin products to increased bleeding risk, including cases in patients on anticoagulants, prompting mandated label warnings. (Source: Summary Safety Review - Diosmin and Hesperidin: Assessing the Potential Increased Risk of Bleeding.)
3 interactions are documented in Magellan's curated dataset: 1 moderate, 2 minor. They cover Anticoagulants (blood thinners), Antiplatelet drugs, Calcium channel blockers, Chemotherapy and cancer therapy, Immunosuppressants. Absence from this list is not proof of safety — it means no interaction is documented in the references we curate from.
Magellan lists the typical studied dose as: ~500 mg/day isolated, or via hesperidin-enriched juice. Dose matters for interactions — several of the entries on this page describe effects that only appear at supplemental rather than dietary intakes.