Broccoli Sprout Sulforaphane, graded Moderate-evidence on Magellan — a 2025 randomized placebo-controlled trial found a small average reduction in fasting glucose (about 0.2 mmol/L), with substantially larger effects in participants whose gut microbiota and metabolic profile predicted response. Magellan links 19 peer-reviewed citations for Broccoli Sprout Sulforaphane.
Source: Nat Microbiol 2025, PMID 39929977 ↗ · Nutraceuticals & Cellular Energizers · How Magellan grades evidence · Study write-up · evidence confidence: high
Sulforaphane is an isothiocyanate phytochemical formed when the plant enzyme myrosinase acts on glucoraphanin, a glucosinolate concentrated in cruciferous vegetables such as broccoli and especially young broccoli sprouts. In the body it is a potent activator of the NRF2 (NF-E2-related factor 2) transcription factor, which induces phase-2 antioxidant and detoxification enzymes. In diabetes research it has been shown to suppress hepatic glucose production by promoting NRF2 nuclear translocation and downregulating key gluconeogenic enzymes. It is commonly delivered as a standardized broccoli sprout extract.
Human trials indicate that concentrated broccoli-sprout sulforaphane can modestly lower fasting blood glucose and glycated hemoglobin, most clearly in obese or dysregulated type 2 diabetes and in a subset of people with prediabetes; a 2025 randomized placebo-controlled trial found a small average reduction in fasting glucose (about 0.2 mmol/L), with substantially larger effects in participants whose gut microbiota and metabolic profile predicted response. A separate line of randomized trials shows sulforaphane-rich preparations enhance the detoxification and excretion of airborne and tobacco-derived carcinogens, and early trials report improved insulin resistance and liver enzymes, with a generally good safety and tolerability profile aside from mild gastrointestinal effects. Benefits so far are biomarker-level rather than proven disease-outcome reductions, and supplement bioavailability varies widely unless the preparation retains active myrosinase. This evidence concerns the sulforaphane compound and broccoli-sprout extracts in general, not this specific commercial product.
Peer-reviewed studies on the active compound — citations link to PubMed.
“reduction in fasting blood glucose compared with placebo”
“Sulforaphane suppressed glucose production; reduced fasting blood glucose and HbA1c”
“sulforaphane activates Nrf2 and delays senescence by decreasing glucose metabolism and oxidative damage”
“After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.”
“No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed.”
“Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress.”
Research describes the active mechanism and is not a claim about this specific product.
Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum…
Across meta-analyses and randomized trials, creatine monohydrate combined with…
In humans, randomized trials and meta-analyses most consistently show that astaxanthin…
Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after…
Yes — its active compound is linked to 19 peer-reviewed studies, summarized and cited above.
You can buy it on Amazon via the link above; Magellan earns a small affiliate commission at no extra cost to you, which does not affect the evidence grade.
Dietary supplements and devices are generally well tolerated but are not a substitute for medical care. Talk to your physician before starting, especially if you take medication or have a health condition.