What are the potential therapeutic effects of beetroot juice (BRJ) in the management of peripheral artery disease (PAD)?
Beetroot / Dietary Nitrate, a review (Nitric Oxide 2025, PMID 40139306) — the review indicates that beetroot juice can improve exercise performance, lower blood pressure, improve endothelial function, enhance skeletal muscle microvascular function, and improve central autonomic nervous system function. No numeric effect size is reported for Beetroot / Dietary Nitrate in the source abstract.
Source: Nitric Oxide 2025, PMID 40139306 ↗ · Research map · How Magellan grades evidence · evidence confidence: low
Nitric Oxide · 2025 · PMID 40139306 · DOI 10.1016/j.niox.2025.03.003
Beetroot juice may improve several markers of cardiovascular health and exercise performance relevant to peripheral artery disease.
The question
What are the potential therapeutic effects of beetroot juice (BRJ) in the management of peripheral artery disease (PAD)?
What they tested
Beetroot juice, rich in nitrate and betaine, may offer therapeutic benefits for PAD by increasing nitric oxide (NO) bioavailability through the nitrate-nitrite-NO pathway, thereby improving blood flow and other physiological functions.
How they did it
This is a review article that explores the potential therapeutic effects of beetroot juice in PAD management by examining existing evidence related to its bioactive compounds and their mechanisms of action, particularly the nitrate-nitrite-NO pathway.
What they found
The review indicates that beetroot juice can improve exercise performance, lower blood pressure, improve endothelial function, enhance skeletal muscle microvascular function, and improve central autonomic nervous system function.
What it means
Beetroot and its rich bioactive compounds show promise as a novel supportive therapy for improving peripheral artery disease.
Limitations
The abstract does not explicitly state any limitations of the review itself, but rather focuses on the potential benefits of beetroot juice.
Where the published abstract does not list limitations, we say so rather than inventing them. Read the full paper on PubMed before drawing conclusions.
The paper at a glance
| Title | Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO pathway) |
|---|---|
| Journal | Nitric Oxide |
| Year | 2025 |
| PMID | 40139306 ↗ |
| DOI | 10.1016/j.niox.2025.03.003 ↗ |
| Topic | Cardiovascular & vascular aging |
Read the source: PubMed record (authors, abstract, full citation) ↗ · Publisher via doi.org ↗
Where Magellan uses this paper
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Beetroot / Dietary Nitrate
Meta-analyses of randomized trials show that beetroot juice and dietary nitrate lower blood pressure—about 5 mmHg systolic on average across trials in hypertension, and in one pivotal placebo-controlled trial in hypertensive patients roughly 7-8 mmHg, including 24-hour ambulatory readings, sustained over four weeks…
Beetroot (Beta vulgaris) is a root vegetable that is one of the richest dietary sources of inorganic…
Research describes the compound or intervention studied. It is not a claim about any specific product.
Molecules & mechanisms in this paper
Each of these is named in the paper’s own words above. Open the monograph for the full mechanism and its other citations.
Cite this page
These citations point at this summary. To cite the original paper with its full author list, use the PubMed record or doi.org.
Magellan Longevity. (2026). What are the potential therapeutic effects of beetroot juice (BRJ) in the management of peripheral artery disease (PAD)? [Plain-English summary of Nitric Oxide 2025, PMID 40139306, DOI 10.1016/j.niox.2025.03.003]. Magellan Longevity. https://magellanlongevity.com/study/beet_no.html@misc{magellan_beet_no,
title = {What are the potential therapeutic effects of beetroot juice (BRJ) in the management of peripheral artery disease (PAD)?},
author = {{Magellan Longevity}},
year = {2026},
howpublished = {\url{https://magellanlongevity.com/study/beet_no.html}},
note = {Plain-English summary of PubMed PMID 40139306; DOI 10.1016/j.niox.2025.03.003; Nitric Oxide 2025. Reviewed by Gabriel Radu, DO},
urldate = {2026-08-11}
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